p70 S6 kinase/S6K1 Antibody (D-4): sc-514501

p70 S6 kinase α Antibody (D-4) is a mouse monoclonal IgM kappa light chain antibody specific for an epitope mapping between amino acids 481-502 at the C-terminus of p70 S6 kinase α of rat origin, detecting p70 S6 kinase α in mouse, rat, and human samples by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p70 S6 kinase α, also known as S6K1 or RPS6KB1, is a serine/threonine kinase integral to the mTOR (mechanistic Target of Rapamycin) signaling pathway, playing a critical role in regulating cell growth, proliferation, and metabolism through phosphorylation of the 40S ribosomal protein S6, which enhances protein synthesis. Structurally, p70 S6 kinase α consists of several key domains, including an N-terminal kinase domain responsible for catalytic activity, a regulatory linker region containing multiple phosphorylation sites, and a C-terminal autoinhibitory domain that modulates activation status. This structural configuration enables precise control over cellular processes through phosphorylation-induced conformational changes within these domains. Aberrations in p70 S6 kinase α can lead to dysregulation of cell growth and are implicated in various diseases including cancer, diabetes, and neurological disorders. Anti-p70 S6 kinase α antibody (D-4) provides reliable detection and analysis across multiple applications, supporting advanced research into structural-functional relationships and disease mechanisms.

The preferred p70 S6 kinase/S6K1 antibody is p70 S6 kinase/S6K1 Antibody (H-9): sc-8418.