p57 Kip2 Antibody (3F245): sc-71823

p57 Kip2 Antibody (3F245) is a mouse monoclonal IgG2b antibody that detects p57 Kip2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. p57 Kip2, also known as Kip2, is a crucial member of the p21 Waf1/Cip1/p27 family of cyclin-dependent kinase inhibitors, playing a significant role in regulating cell cycle progression by inhibiting several G1 cyclin/Cdk complexes. This inhibition is vital for maintaining proper cell cycle control, particularly in response to cellular stress or DNA damage, as p57 Kip2 prevents uncontrolled cell proliferation. Unlike p21 Waf1/Cip1, p57 Kip2 operates independently of p53 regulation, which allows p57 Kip2 to exert effects even in p53-deficient contexts. The tight-binding nature of p57 Kip2 to cyclin/Cdk complexes underscores p57 Kip2′s potency as a negative regulator of G1 progression, making p57 Kip2 an important target for studies related to cell cycle dysregulation in various diseases, including cancer. With an ability to arrest cells in G1 phase, p57 Kip2 serves as a critical checkpoint in cellular responses to growth signals, thereby influencing both normal development and tumorigenesis.

The preferred p57 Kip2 antibody is p57 Kip2 Antibody (KP39): sc-56341.