p53RFP Antibody (U-16): sc-101247

p53RFP Antibody (U-16) is a mouse monoclonal IgG2a kappa light chain antibody that detects p53RFP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-p53RFP antibody (U-16) is available as the non-conjugated format. p53RFP protein plays a crucial role in regulating cell cycle and apoptosis, acting as a key player in cellular response to stress and DNA damage. Specifically, p53RFP, also known as IBRDC2, functions as an E3 ubiquitin ligase, facilitating ubiquitination and subsequent degradation of target proteins that may otherwise promote cell cycle progression. This post-translational modification helps maintain cellular homeostasis and prevents damaged DNA propagation, thereby safeguarding against tumorigenesis. p53RFP interaction with specific E2 ubiquitin-conjugating enzymes underscores p53RFP importance in the ubiquitin-proteasome pathway, which is essential for regulating various cellular processes, including cell cycle and apoptosis. Using p53RFP monoclonal antibody (U-16), researchers can gain insights into p53RFP expression dynamics and implications in cancer biology, particularly in understanding how p53RFP dysregulation may contribute to tumor development and progression.

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p53RFP Antibody (U-16) References:

1. p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1.  |  Ng, CC., et al. 2003. Oncogene. 22: 4449-58. PMID: 12853982
2. Isolation of p53-target genes and their functional analysis.  |  Nakamura, Y. 2004. Cancer Sci. 95: 7-11. PMID: 14720320
3. p53 mutations in human cancers.  |  Hollstein, M., et al. 1991. Science. 253: 49-53. PMID: 1905840
4. Participation of p53 protein in the cellular response to DNA damage.  |  Kastan, MB., et al. 1991. Cancer Res. 51: 6304-11. PMID: 1933891
5. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.  |  Fakharzadeh, SS., et al. 1991. EMBO J. 10: 1565-9. PMID: 2026149
6. Cancer. A deadly inheritance.  |  Vogelstein, B. Nature. 348: 681-2. PMID: 2259380
7. Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.  |  Chen, CY., et al. 1994. Proc Natl Acad Sci U S A. 91: 2684-8. PMID: 8146175
8. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53.  |  Oliner, JD., et al. 1993. Nature. 362: 857-60. PMID: 8479525

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p53RFP Antibody (U-16) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-p53RFP Antibody (U-16) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p53RFP Antibody (U-16) Specifications

Alternate Product Name: p53RFP

Product Clone Name: U-16

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-101

Epitope Target: p53RFP

Epitope Species: human

Product Reactivity/Detection: p53RFP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for p53RFP Antibody (U-16): N/A