Date published: 2025-12-18

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p53RFP Inhibitors

The p53RFP inhibitors represent a distinctive class of chemical compounds designed to modulate the activity of the p53 protein, a crucial player in the regulation of cell cycle and prevention of uncontrolled cell growth. The p53 protein serves as a tumor suppressor by orchestrating cellular responses to stressors such as DNA damage. In certain pathological conditions, including cancer, the normal functioning of p53 may be compromised, leading to unchecked cell proliferation. The development of p53RFP inhibitors has arisen from the imperative to fine-tune p53 activity, thereby potentially influencing cellular fate.

p53RFP inhibitors encompass a diverse range of molecules with a shared affinity for the p53 protein. These inhibitors function by binding to specific sites on the p53 protein, modulating its conformation or impeding its interactions with other cellular components. By doing so, they may either enhance or attenuate the activity of p53, depending on the specific objectives of the inhibitor design. Researchers aim to unravel the intricate mechanisms through which p53RFP inhibitors exert their effects, deciphering the nuances of their interactions with the p53 protein. This class of compounds holds promise in shedding light on the regulatory pathways of p53 and may pave the way for novel strategies in manipulating cellular responses to stress, potentially influencing cellular fate in diverse physiological contexts. The ongoing exploration of p53RFP inhibitors marks a significant step in unraveling the complexities of cellular signaling pathways and their implications for various biological processes.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Nutlin-3

548472-68-0sc-45061
sc-45061A
sc-45061B
1 mg
5 mg
25 mg
$56.00
$212.00
$764.00
24
(1)

Disrupts the interaction between p53 and MDM2, leading to stabilization and activation of p53, which indirectly can diminish its availability for certain cellular responses.

Roscovitine

186692-46-6sc-24002
sc-24002A
1 mg
5 mg
$92.00
$260.00
42
(2)

Targets CDK2 and can prevent phosphorylation of p53, affecting its activity.

2-Vinyl-4-quinazolinol

91634-12-7sc-308709
250 mg
$143.00
(0)

A small molecule that was identified to reactivate mutant p53 in certain contexts, possibly altering its cell cycle control functions.

CP 31398 dihydrochloride

259199-65-0sc-205270
sc-205270A
10 mg
50 mg
$107.00
$425.00
(0)

Stabilizes the active conformation of p53, which might lead to a paradoxical inhibition of its downstream effects due to feedback mechanisms.

PRIMA-1MET

5291-32-7sc-361295
sc-361295A
10 mg
25 mg
$150.00
$319.00
5
(1)

A derivative of PRIMA-1, which can restore wild-type function to mutant p53, possibly affecting its normal regulatory roles.