p38IP Antibody (C-7): sc-374665

p38IP Antibody (C-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects p38IP of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p38IP (C-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. p38IP, also known as C13, FP757, SPT20, FAM48A, C13orf19, or SUPT20H, is a 779 amino acid protein that plays a crucial role in cellular signaling by interacting with p38 MAP kinase, which is essential for the downregulation of E-cadherin during gastrulation. This process is vital for proper embryonic development, as E-cadherin is a key protein involved in cell adhesion and maintaining tissue integrity. p38IP is predominantly expressed in the testis and shows moderate expression levels in the brain and pituitary gland, while also being present in several fetal tissues such as the lung, brain, thymus, and kidney. p38IP expression has been found to be downregulated in malignant prostate tissues, suggesting a potential role as a tumor suppressor. The gene encoding p38IP is located on human chromosome 13, which contains over 400 genes and is significant for housing key tumor suppressor genes, including BRCA2 and RB1, highlighting the importance of p38IP in both normal physiology and disease states.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

p38IP Antibody (C-7) References:

1. The DNA sequence and analysis of human chromosome 13.  |  Dunham, A., et al. 2004. Nature. 428: 522-8. PMID: 15057823
2. Quantification of C13orf19/P38IP mRNA expression by quantitative real-time PCR in patients with urological malignancies.  |  Schmidt, U., et al. 2005. Cancer Lett. 225: 253-60. PMID: 15978328
3. Functional analyses of C13orf19/P38IP in prostate cell lines.  |  Kunze, D., et al. 2006. Oncol Rep. 15: 1599-604. PMID: 16685401
4. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.  |  Zohn, IE., et al. 2006. Cell. 125: 957-69. PMID: 16751104
5. RB and cell cycle progression.  |  Giacinti, C. and Giordano, A. 2006. Oncogene. 25: 5220-7. PMID: 16936740
6. Non-disjunction of chromosome 13.  |  Bugge, M., et al. 2007. Hum Mol Genet. 16: 2004-10. PMID: 17584770
7. Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.  |  Hassler, M., et al. 2007. Mol Cell. 28: 371-85. PMID: 17996702
8. BRCA2: a universal recombinase regulator.  |  Thorslund, T. and West, SC. 2007. Oncogene. 26: 7720-30. PMID: 18066084

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p38IP Antibody (C-7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-p38IP Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p38IP Antibody (C-7) Specifications

Alternate Product Name: p38IP

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 308-423

Epitope Target: p38IP

Epitope Species: human

Product Reactivity/Detection: p38IP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for p38IP Antibody (C-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin