p38 gamma MAPK12 Antibody (G-9): sc-515269

p38 gamma MAPK12 Antibody (G-9) is a mouse monoclonal IgG2b antibody that detects p38 gamma MAPK12 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p38 gamma MAPK12, a member of the mitogen-activated protein kinase family, plays a crucial role in various cellular processes, including stress responses, inflammation, and cell differentiation. p38 gamma MAPK12 is primarily located in the cytoplasm, where activation occurs in response to environmental stressors and cytokines, leading to the phosphorylation of downstream targets that regulate gene expression and cell cycle progression. Proper functioning of p38 gamma MAPK12 is vital for maintaining cellular homeostasis and responding to external stimuli, making p38 gamma MAPK12 an important player in both normal physiology and disease states. p38 gamma MAPK12 interacts with several key proteins, including MKK3 and MKK6, which are upstream activators that facilitate activation through phosphorylation. anti-p38 gamma MAPK12 antibody (G-9) is an essential tool for researchers studying the intricate signaling pathways involving p38 gamma MAPK12 and its implications in various biological contexts.

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p38 gamma MAPK12 Antibody (G-9) References:

1. p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle.  |  Ho, RC., et al. 2004. Am J Physiol Regul Integr Comp Physiol. 286: R342-9. PMID: 14592936
2. The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.  |  Tosti, E., et al. 2004. J Biol Chem. 279: 47652-60. PMID: 15342622
3. p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.  |  Sabio, G., et al. 2005. EMBO J. 24: 1134-45. PMID: 15729360
4. p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.  |  Hou, S., et al. 2012. J Biol Chem. 287: 27895-905. PMID: 22730326
5. NMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38γ.  |  Aoto, PC., et al. 2016. Sci Rep. 6: 28655. PMID: 27353957
6. ErbB2 and p38γ MAPK mediate alcohol-induced increase in breast cancer stem cells and metastasis.  |  Xu, M., et al. 2016. Mol Cancer. 15: 52. PMID: 27416801
7. The K-Ras effector p38γ MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation.  |  Yin, N., et al. 2017. J Biol Chem. 292: 15070-15079. PMID: 28739874
8. Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same.  |  Sahu, V., et al. 2019. Cancer Res Treat. 51: 313-325. PMID: 29747487
9. Impact of p38γ mitogen-activated protein kinase (MAPK) on MDA-MB-231 breast cancer cells using metabolomic approach.  |  Chen, H., et al. 2019. Int J Biochem Cell Biol. 107: 6-13. PMID: 30447427
10. p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin.  |  Loonat, AA., et al. 2019. FASEB J. 33: 13131-13144. PMID: 31638431

The preferred p38 gamma MAPK12 antibody is p38 gamma MAPK12 Antibody (E-4): sc-398546.