p38 gamma MAPK12 Antibody (E-5): sc-365550

p38 gamma MAPK12 Antibody (E-5) is a mouse monoclonal IgG3 antibody that detects p38 gamma MAPK12 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p38 gamma MAPK12, a member of the mitogen-activated protein kinase family, plays a crucial role in various cellular processes, including stress responses, inflammation, and cell differentiation. p38 gamma MAPK12 is primarily located in the cytoplasm, where activation occurs in response to environmental stressors and cytokines, leading to phosphorylation of downstream targets that regulate gene expression and cell cycle progression. Proper functioning of p38 gamma MAPK12 is vital for maintaining cellular homeostasis and responding to external stimuli, making p38 gamma MAPK12 an important player in both normal physiology and disease states. p38 gamma MAPK12 interacts with several key proteins, including MKK3 and MKK6, which are upstream activators that facilitate activation through phosphorylation. anti-p38 gamma MAPK12 antibody (E-5) is an essential tool for researchers studying the intricate signaling pathways involving p38 gamma MAPK12 and its implications in various biological contexts.

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p38 gamma MAPK12 Antibody (E-5) References:

1. p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.  |  Qi, X., et al. 2007. J Biol Chem. 282: 31398-408. PMID: 17724032
2. PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction.  |  Hou, SW., et al. 2010. Cancer Res. 70: 2901-10. PMID: 20332238
3. Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death.  |  Kukkonen-Macchi, A., et al. 2011. J Cell Sci. 124: 216-27. PMID: 21172807
4. p38γ overexpression in gliomas and its role in proliferation and apoptosis.  |  Yang, K., et al. 2013. Sci Rep. 3: 2089. PMID: 23807566
5. Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation.  |  Chen, KE., et al. 2014. Sci Signal. 7: ra98. PMID: 25314968
6. Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.  |  Zur, R., et al. 2015. Oncotarget. 6: 12920-35. PMID: 26079427
7. ErbB4 Activated p38γ MAPK Isoform Mediates Early Cardiogenesis Through NKx2.5 in Human Pluripotent Stem Cells.  |  Ramachandra, CJ., et al. 2016. Stem Cells. 34: 288-98. PMID: 26418945
8. Chronic ethanol exposure enhances the aggressiveness of breast cancer: the role of p38γ.  |  Xu, M., et al. 2016. Oncotarget. 7: 3489-505. PMID: 26655092
9. Role of p38γ MAPK in regulation of EMT and cancer stem cells.  |  Xu, M., et al. 2018. Biochim Biophys Acta Mol Basis Dis. 1864: 3605-3617. PMID: 30251680
10. Targeting the non-ATP-binding pocket of the MAP kinase p38γ mediates a novel mechanism of cytotoxicity in cutaneous T-cell lymphoma (CTCL).  |  Zhang, XH., et al. 2021. FEBS Lett. 595: 2570-2592. PMID: 34455585

The preferred p38 gamma MAPK12 antibody is p38 gamma MAPK12 Antibody (E-4): sc-398546.