p38 beta MAPK11 Antibody (F-3): sc-390984

p38 beta MAPK11 Antibody (F-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects p38 beta MAPK11 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p38 beta MAPK11 Antibody (F-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. p38 beta MAPK11 plays a crucial role in cellular signaling pathways, particularly in response to stress stimuli, and is involved in regulating important processes such as inflammation, cell differentiation, and apoptosis. p38 beta MAPK11 is primarily located in the cytoplasm, where activation occurs by phosphorylation in response to various extracellular signals, allowing signal transduction that influences gene expression and cellular responses. Proper functioning of p38 beta MAPK11 is vital for maintaining cellular homeostasis and responding to environmental changes, making p38 beta MAPK11 a key player in various physiological and pathological processes. p38 beta MAPK11 interacts with other proteins within the MAP kinase signaling cascade, including p38 alpha MAPK14 and p38 gamma MAPK12, which collectively coordinate cellular responses to stress and inflammatory signals. Phosphorylation of p38 beta MAPK11 on threonine and tyrosine residues is essential for activation, underscoring the importance of post-translational modifications in regulating activity and function within the cell.

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p38 beta MAPK11 Antibody (F-3) References:

1. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.  |  Tamura, K., et al. 2000. Cell. 102: 221-31. PMID: 10943842
2. Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.  |  Sudo, T., et al. 2002. Biochem Biophys Res Commun. 291: 838-43. PMID: 11866441
3. Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3).  |  Court, NW., et al. 2002. J Mol Cell Cardiol. 34: 413-26. PMID: 11991731
4. Active mutants of the human p38alpha mitogen-activated protein kinase.  |  Diskin, R., et al. 2004. J Biol Chem. 279: 47040-9. PMID: 15284239
5. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.  |  Zohn, IE., et al. 2006. Cell. 125: 957-69. PMID: 16751104
6. T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells.  |  Dziegielewska, B., et al. 2014. Mol Cancer Res. 12: 348-58. PMID: 24362252
7. RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy.  |  Luan, Q., et al. 2015. Autophagy. 11: 975-94. PMID: 26018731
8. Microcystin-Leucine Arginine Causes Cytotoxic Effects in Sertoli Cells Resulting in Reproductive Dysfunction in Male Mice.  |  Chen, Y., et al. 2016. Sci Rep. 6: 39238. PMID: 27976743
9. Molecular cloning of human p38 MAP kinase.  |  Han, J., et al. 1995. Biochim Biophys Acta. 1265: 224-7. PMID: 7696354
10. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.  |  Lee, JC., et al. Nature. 372: 739-46. PMID: 7997261
11. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).  |  Jiang, Y., et al. 1996. J Biol Chem. 271: 17920-6. PMID: 8663524
12. The primary structure of p38 gamma: a new member of p38 group of MAP kinases.  |  Li, Z., et al. 1996. Biochem Biophys Res Commun. 228: 334-40. PMID: 8920915

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p38 beta MAPK11 Antibody (F-3) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-p38 beta MAPK11 Antibody (F-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p38 beta MAPK11 Antibody (F-3) Specifications

Alternate Product Name: p38 beta MAPK11

Product Clone Name: F-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 38-57

Epitope Target: p38 beta MAPK11

Epitope Species: human

Product Reactivity/Detection: p38 beta MAPK11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for p38 beta MAPK11 Antibody (F-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred p38 alpha/beta MAPK antibody is p38 alpha/beta MAPK Antibody (A-12): sc-7972.