p38 beta MAPK11 Antibody (4H6H6): sc-101427

p38 beta MAPK11 Antibody (4H6H6) is a mouse monoclonal IgG1 antibody that detects p38 beta MAPK11 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). p38 beta MAPK11, a member of the mitogen-activated protein kinase family, plays a crucial role in various cellular processes, including stress responses, inflammation, and cell differentiation. p38 beta MAPK11 is primarily located in the cytoplasm, where activation occurs in response to environmental stressors and cytokines, leading to phosphorylation of downstream targets that regulate gene expression and cell cycle progression. Proper functioning of p38 beta MAPK11 is vital for maintaining cellular homeostasis and responding to external stimuli, making p38 beta MAPK11 an important player in both normal physiology and disease states. p38 beta MAPK11 interacts with other proteins such as MAPKAPK2 and MK2, which are involved in the same signaling pathways, further emphasizing p38 beta MAPK11′s significance in cellular signaling networks. anti-p38 beta MAPK11 antibody (4H6H6) is an essential tool for researchers studying these critical pathways and their implications in various biological contexts.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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p38 beta MAPK11 Antibody (4H6H6) References:

1. Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression.  |  Mahlknecht, U., et al. 2004. J Immunol. 173: 3979-90. PMID: 15356147
2. Epidermal growth factor stimulation of trophoblast differentiation requires MAPK11/14 (p38 MAP kinase) activation.  |  Johnstone, ED., et al. 2005. Biol Reprod. 73: 1282-8. PMID: 16120828
3. T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells.  |  Dziegielewska, B., et al. 2014. Mol Cancer Res. 12: 348-58. PMID: 24362252
4. RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy.  |  Luan, Q., et al. 2015. Autophagy. 11: 975-94. PMID: 26018731
5. The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research.  |  Menon, MB., et al. 2015. Autophagy. 11: 1425-7. PMID: 26061537
6. Microcystin-Leucine Arginine Causes Cytotoxic Effects in Sertoli Cells Resulting in Reproductive Dysfunction in Male Mice.  |  Chen, Y., et al. 2016. Sci Rep. 6: 39238. PMID: 27976743
7. P38-β/SAPK-inhibiting and apoptosis-inducing activities of (E)-4-chloro-2-((3-ethoxy-2-hydroxybenzylidene) amino)phenol.  |  Karaosmanoğlu, O. 2020. Hum Exp Toxicol. 39: 1374-1389. PMID: 32394730
8. p38β (MAPK11) mediates gemcitabine-associated radiosensitivity in sarcoma experimental models.  |  Pascual-Serra, R., et al. 2021. Radiother Oncol. 156: 136-144. PMID: 33310004
9. The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection.  |  Shariq, M., et al. 2023. Autophagy. 19: 3-23. PMID: 35000542
10. Microarray meta-analysis reveals IL6 and p38β/MAPK11 as potential targets of hsa-miR-124 in endothelial progenitor cells: Implications for stent re-endothelization in diabetic patients.  |  Arencibia, A. and Salazar, LA. 2022. Front Cardiovasc Med. 9: 964721. PMID: 36176980

The preferred p38 alpha/beta MAPK antibody is p38 alpha/beta MAPK Antibody (A-12): sc-7972.