p38 alpha MAPK14 Antibody (9F12): sc-81621

p38 alpha MAPK14 Antibody (9F12) is a mouse monoclonal IgG1 kappa light chain antibody specifically engineered to recognize p38 alpha MAPK14, also known as p38α, CSBP, MXI2, or MAP kinase 14, across mouse, rat, and human species. p38 alpha MAPK14 monoclonal antibody (9F12) is raised against the full-length recombinant human p38 alpha MAPK14 and is effective in a variety of applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). p38 alpha MAPK14 is a critical member of the mitogen-activated protein kinase (MAPK) family, distinguished by its single protein kinase domain which is essential for its role in cellular signaling pathways. The structure of p38 alpha MAPK14, particularly its kinase domain and dependence on magnesium as a cofactor, is fundamental to its ATP-dependent phosphorylation activity, allowing modification of target proteins by adding phosphate groups to threonine and tyrosine residues. This structural configuration is pivotal for involvement in key biological processes such as cell adhesion, spreading, differentiation, and apoptosis. Understanding the intricate structure of p38 alpha MAPK14 enables researchers to elucidate its function in various signal transduction pathways, cytokine production, and cell proliferation. anti-p38 alpha MAPK14 antibody (9F12) is available in both non-conjugated form and multiple conjugated variants, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing flexibility for diverse experimental requirements.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

p38 alpha MAPK14 Antibody (9F12) References:

1. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.  |  Tamura, K., et al. 2000. Cell. 102: 221-31. PMID: 10943842
2. Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.  |  Sudo, T., et al. 2002. Biochem Biophys Res Commun. 291: 838-43. PMID: 11866441
3. Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3).  |  Court, NW., et al. 2002. J Mol Cell Cardiol. 34: 413-26. PMID: 11991731
4. Active mutants of the human p38alpha mitogen-activated protein kinase.  |  Diskin, R., et al. 2004. J Biol Chem. 279: 47040-9. PMID: 15284239
5. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.  |  Zohn, IE., et al. 2006. Cell. 125: 957-69. PMID: 16751104
6. Molecular cloning of human p38 MAP kinase.  |  Han, J., et al. 1995. Biochim Biophys Acta. 1265: 224-7. PMID: 7696354
7. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.  |  Lee, JC., et al. Nature. 372: 739-46. PMID: 7997261
8. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).  |  Jiang, Y., et al. 1996. J Biol Chem. 271: 17920-6. PMID: 8663524
9. The primary structure of p38 gamma: a new member of p38 group of MAP kinases.  |  Li, Z., et al. 1996. Biochem Biophys Res Commun. 228: 334-40. PMID: 8920915

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p38 alpha MAPK14 Antibody (9F12) has 96 citations in a variety of scientific publications.

Primary antibodies like Anti-p38 alpha MAPK14 Antibody (9F12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p38 alpha MAPK14 Antibody (9F12) Specifications

Alternate Product Name: p38 alpha MAPK14

Product Clone Name: 9F12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: p38 alpha MAPK14

Epitope Species: human

Product Reactivity/Detection: p38 alpha MAPK14

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 96 citations in various scientific publications

Available Conjugates/Forms for p38 alpha MAPK14 Antibody (9F12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred p38 alpha/beta MAPK antibody is p38 alpha/beta MAPK Antibody (A-12): sc-7972.