P2Y13 Antibody (6G12E10): sc-517219

P2Y13 Antibody (6G12E10) is a mouse monoclonal IgG1 antibody that detects P2Y13 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). P2Y13 (6G12E10) antibody is available as the non-conjugated anti-P2Y13 antibody. P2Y13 protein, also known as purinergic receptor P2Y, G-protein coupled, 13, is a 354 amino acid multi-pass membrane protein that plays a crucial role in the immune system and hematopoiesis by acting as a receptor for adenosine diphosphate (ADP). P2Y13 is part of the P2Y family of G protein-coupled receptors, which are activated by extracellular nucleotides and are essential for mediating various physiological processes, including cell proliferation and differentiation. P2Y13 is predominantly expressed in the spleen and adult brain tissue, where P2Y13 contributes to the regulation of immune responses and the development of blood cells. P2Y13′s ability to interact with other signaling pathways highlights P2Y13′s importance in maintaining cellular homeostasis and responding to extracellular signals, making P2Y13 a valuable target for research in immunology and hematology.

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P2Y13 Antibody (6G12E10) References:

1. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors.  |  Wittenberger, T., et al. 2001. J Mol Biol. 307: 799-813. PMID: 11273702
2. Identification of a novel human ADP receptor coupled to G(i).  |  Communi, D., et al. 2001. J Biol Chem. 276: 41479-85. PMID: 11546776
3. Discovery and mapping of ten novel G protein-coupled receptor genes.  |  Lee, DK., et al. 2001. Gene. 275: 83-91. PMID: 11574155
4. P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse.  |  Zhang, FL., et al. 2002. J Pharmacol Exp Ther. 301: 705-13. PMID: 11961076
5. Identification of G protein-coupled receptor genes from the human genome sequence.  |  Takeda, S., et al. 2002. FEBS Lett. 520: 97-101. PMID: 12044878
6. ADP acting on P2Y13 receptors is a negative feedback pathway for ATP release from human red blood cells.  |  Wang, L., et al. 2005. Circ Res. 96: 189-96. PMID: 15604418
7. Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor.  |  Kim, YC., et al. 2005. Biochem Pharmacol. 70: 266-74. PMID: 15913566
8. The nucleotide receptor P2Y13 is a key regulator of hepatic high-density lipoprotein (HDL) endocytosis.  |  Jacquet, S., et al. 2005. Cell Mol Life Sci. 62: 2508-15. PMID: 16231090
9. RhoA/ROCK I signalling downstream of the P2Y13 ADP-receptor controls HDL endocytosis in human hepatocytes.  |  Malaval, C., et al. 2009. Cell Signal. 21: 120-7. PMID: 18948190

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-P2Y13 Antibody (6G12E10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-P2Y13 Antibody (6G12E10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

P2Y13 Antibody (6G12E10) Specifications

Alternate Product Name: P2Y13

Product Clone Name: 6G12E10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 1-49

Epitope Target: P2Y13

Epitope Species: human

Product Reactivity/Detection: P2Y13

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for P2Y13 Antibody (6G12E10): N/A