P2P-R Antibody (M56): sc-9962
- P2P-R Antibody (M56) is a mouse monoclonal IgM κ P2P-R antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 753-909 of P2P-R of mouse origin
- P2P-R Antibody (M56) is recommended for detection of P2P-R of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-P2P-R Antibody (M56) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for P2P-R Antibody (M56) for WB and IHC(P) applications. This reagent is now offered in a bundle with P2P-R Antibody (M56) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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P2P-R Antibody (M56) is a mouse monoclonal IgM antibody that detects P2P-R of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. P2P-R (M56) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. P2P-R, also known as PACT (p53 associated cellular protein-testis derived), plays a crucial role in the regulation of the cell cycle by interacting with key proteins such as p53 and retinoblastoma (Rb). P2P-R has been shown to bind to wildtype p53, inhibiting specific DNA binding capabilities, which is vital for maintaining genomic stability and preventing tumorigenesis. P2P-R interaction with Rb is particularly important as this suggests a mechanism through which P2P-R may influence cell cycle progression and checkpoint regulation. Additionally, RBQ-1 identification, a protein that binds to Rb, highlights the intricate network of protein-protein interactions that govern cellular functions and responses to stress. Understanding these interactions is essential for elucidating pathways involved in cancer development and progression, making anti-P2P-R antibody (M56) a valuable tool for researchers studying these critical processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
P2P-R Antibody (M56) References:
- The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. | Momand, J., et al. 1992. Cell. 69: 1237-45. PMID: 1535557
- The E2F transcription factor is a cellular target for the RB protein. | Chellappan, SP., et al. 1991. Cell. 65: 1053-61. PMID: 1828392
- T antigen is bound to a host protein in SV40-transformed cells. | Lane, DP. and Crawford, LV. 1979. Nature. 278: 261-3. PMID: 218111
- SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. | DeCaprio, JA., et al. 1988. Cell. 54: 275-83. PMID: 2839300
- Mouse p53 blocks SV40 DNA replication in vitro and downregulates T antigen DNA helicase activity. | Stürzbecher, HW., et al. 1988. Oncogene. 3: 405-13. PMID: 2856250
- WAF1, a potential mediator of p53 tumor suppression. | el-Deiry, WS., et al. 1993. Cell. 75: 817-25. PMID: 8242752
- cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product. | Sakai, Y., et al. 1995. Genomics. 30: 98-101. PMID: 8595913
- PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb. | Simons, A., et al. 1997. Oncogene. 14: 145-55. PMID: 9010216
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
P2P-R Antibody (M56) | sc-9962 | 200 µg/ml | $316.00 | |||
P2P-R Antibody (M56): m-IgGκ BP-HRP Bundle | sc-551561 | 200 µg Ab; 40 µg BP | $354.00 | |||
P2P-R Antibody (M56) AC | sc-9962 AC | 500 µg/ml, 25% agarose | $416.00 | |||
P2P-R Antibody (M56) HRP | sc-9962 HRP | 200 µg/ml | $316.00 | |||
P2P-R Antibody (M56) FITC | sc-9962 FITC | 200 µg/ml | $330.00 | |||
P2P-R Antibody (M56) PE | sc-9962 PE | 200 µg/ml | $343.00 | |||
P2P-R Antibody (M56) Alexa Fluor® 488 | sc-9962 AF488 | 200 µg/ml | $357.00 | |||
P2P-R Antibody (M56) Alexa Fluor® 546 | sc-9962 AF546 | 200 µg/ml | $357.00 | |||
P2P-R Antibody (M56) Alexa Fluor® 594 | sc-9962 AF594 | 200 µg/ml | $357.00 | |||
P2P-R Antibody (M56) Alexa Fluor® 647 | sc-9962 AF647 | 200 µg/ml | $357.00 | |||
P2P-R Antibody (M56) Alexa Fluor® 680 | sc-9962 AF680 | 200 µg/ml | $357.00 | |||
P2P-R Antibody (M56) Alexa Fluor® 790 | sc-9962 AF790 | 200 µg/ml | $357.00 |