CDKN1B/Kip1 p27 Antibody (DCS-72): sc-56338

p27 Kip1 Antibody (DCS-72) is a mouse monoclonal IgG1 kappa light chain antibody that detects p27 Kip1 protein in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p27 Kip1 Antibody (DCS-72) comes in non-conjugated form and various conjugated options, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. p27 Kip1 protein regulates cell cycle progression during G1 phase by inhibiting cyclin-dependent kinases (Cdks), preventing transition to S phase. This regulation maintains proper cell proliferation and prevents uncontrolled cell growth associated with cancer development. p27 Kip1 functions primarily in the nucleus, interacting with D-type cyclins and Cdk4 to modulate their activity. Various signaling pathways influence p27 Kip1 levels, including transforming growth factor-beta (TGFβ)-activated pathways that can trigger G1 arrest, demonstrating p27 Kip1′s role in cellular stress and damage responses. Using anti-p27 Kip1 antibody (DCS-72) enables researchers to explore cell cycle regulation mechanisms and their implications in cancer biology and therapeutic development.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CDKN1B/Kip1 p27 Antibody (DCS-72) has 31 citations in a variety of scientific publications.

Primary antibodies like Anti-CDKN1B/Kip1 p27 Antibody (DCS-72) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CDKN1B/Kip1 p27 Antibody (DCS-72) Specifications

Alternate Product Name: p27 Kip1

Product Clone Name: DCS-72

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: p27 Kip1

Epitope Species: mouse

Product Reactivity/Detection: p27 Kip1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 31 citations in various scientific publications

Available Conjugates/Forms for CDKN1B/Kip1 p27 Antibody (DCS-72): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred CDKN1B/Kip1 p27 antibody is CDKN1B/Kip1 p27 Antibody (F-8): sc-1641.