CDKN1B/Kip1 p27 Antibody (D-2): sc-393305
- CDKN1B/Kip1 p27 Antibody (D-2) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 173-198 at the C-terminus of p27 Kip1 of human origin
- recommended for detection of p27 Kip1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and bovine
- See CDKN1B/Kip1 p27 (F-8): sc-1641 for CDKN1B/Kip1 p27 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CDKN1B/Kip1 p27 Antibody (D-2) for WB applications. These reagents are now offered in bundles with CDKN1B/Kip1 p27 Antibody (D-2) (see ordering information below).
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SEE ALSO...
p27 Kip1 Antibody (D-2) is a mouse monoclonal IgG1 antibody that detects p27 Kip1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p27 Kip1 plays a crucial role in regulating the cell cycle by acting as a negative regulator of G1 progression, which is essential for maintaining proper cellular function and preventing uncontrolled cell division that can lead to cancer. p27 Kip1 is primarily located in the nucleus, where p27 Kip1 binds to cyclin-dependent kinases, particularly D-type cyclins and Cdk4, thereby inhibiting their activity and preventing the transition from the G1 phase to the S phase of the cell cycle. p27 Kip1 regulation is vital, as p27 Kip1 levels can be influenced by various signaling pathways, including TGFβ, which can induce G1 arrest, highlighting p27 Kip1′s importance in cellular responses to stress and damage. anti-p27 Kip1 antibody (D-2) is an invaluable tool for researchers studying cell cycle regulation and the mechanisms underlying tumorigenesis, providing insights into the intricate balance of cell proliferation and growth control.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDKN1B/Kip1 p27 Antibody (D-2) | sc-393305 | 200 µg/ml | $322.00 | |||
CDKN1B/Kip1 p27 Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-540896 | 200 µg Ab; 10 µg BP | $361.00 | |||
CDKN1B/Kip1 p27 Antibody (D-2): m-IgG1 BP-HRP Bundle | sc-542448 | 200 µg Ab; 20 µg BP | $361.00 | |||
CDKN1B/Kip1 p27 (D-2) Neutralizing Peptide | sc-393305 P | 100 µg/0.5 ml | $69.00 |