P23 Antibody (16): sc-136021
- P23 Antibody (16) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 1-94 of P23 of mouse origin
- recommended for detection of P23 of mouse and rat origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for P23 Antibody (16). This work is in progress.
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P23 Antibody (16) is a mouse monoclonal IgG1 antibody that detects P23 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a ubiquitously expressed protein that serves as a cochaperone within the HSP 90-based molecular chaperone complex, playing a crucial role in signal transduction. P23 is primarily localized in the cytoplasm, where P23 interacts with various steroid receptors, including the glucocorticoid receptor (GR) and estrogen receptor alpha (ERα). P23′s interaction with these receptors facilitates the proper folding and maturation of these steroid complexes, thereby regulating the expression of genes associated with hormone signaling. Notably, P23′s ability to disrupt receptor-mediated transcriptional activation underscores P23′s importance in modulating cellular responses to hormonal stimuli. Furthermore, P23 upregulation has been linked to the invasion and metastasis of various cancers, highlighting P23′s potential as a biomarker for cancer progression and a target for therapeutic intervention. Anti-P23 antibody (16) is an essential tool for researchers investigating the intricate roles of P23 in cellular signaling and disease mechanisms.
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P23 Antibody (16) References:
- The transmembrane protein p23 contributes to the organization of the Golgi apparatus. | Rojo, M., et al. 2000. J Cell Sci. 113 (Pt 6): 1043-57. PMID: 10683152
- The influence of ATP and p23 on the conformation of hsp90. | Sullivan, WP., et al. 2002. J Biol Chem. 277: 45942-8. PMID: 12324468
- The Hsp90 cochaperone p23 is essential for perinatal survival. | Grad, I., et al. 2006. Mol Cell Biol. 26: 8976-83. PMID: 17000766
- p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains. | Wang, H. and Kazanietz, MG. 2010. Mol Biol Cell. 21: 1398-408. PMID: 20164256
- p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines. | Nguyen, PM., et al. 2012. Biochem Pharmacol. 84: 838-50. PMID: 22759865
- The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status. | Zelin, E., et al. 2012. Mol Cell. 48: 459-70. PMID: 23022381
- Characterization of an Hsp90-Independent Interaction between Co-Chaperone p23 and Transcription Factor p53. | Wu, H., et al. 2018. Biochemistry. 57: 935-944. PMID: 29334217
- Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease. | Rane, A., et al. 2018. Neurotoxicology. 65: 166-173. PMID: 29471019
- Acute Myeloid Leukemia with t(6;9)(p23;q34.1); DEK-NUP214: The Pathogenesis and Potential. | Gardner, JA., et al. 2020. J Assoc Genet Technol. 46: 98-102. PMID: 32526729
- p23, a major COPI-vesicle membrane protein, constitutively cycles through the early secretory pathway. | Nickel, W., et al. 1997. Proc Natl Acad Sci U S A. 94: 11393-8. PMID: 9326620
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
P23 Antibody (16) | sc-136021 | 50 µg/0.5 ml | $316.00 |