p19 INK4D/CDKN2D Antibody (DCS-100): sc-56334

p19 INK4D Antibody (DCS-100) is a mouse monoclonal IgG1 kappa light chain antibody that detects p19 INK4D of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-p19 INK4D antibody (DCS-100) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. p19 INK4D plays a crucial role in regulating the cell cycle by specifically inhibiting the activities of cyclin-dependent kinases Cdk4 and Cdk6, which are essential for the transition from the G1 phase to the S phase of the cell cycle. This inhibition is vital for maintaining proper cell cycle control, as dysregulation can lead to uncontrolled cell proliferation and contribute to tumorigenesis. Notably, p19 INK4D is expressed at its highest levels during the S phase, and overexpression can induce G1 arrest, highlighting p19 INK4D′s importance in cellular responses to growth signals and stress. The gene encoding p19 INK4D is located in close proximity to the p16 INK4A gene on chromosome 9p21.3, a region frequently associated with chromosomal abnormalities in various human cancers. p19 INK4D monoclonal antibody (DCS-100) enables researchers to gain valuable insights into the mechanisms of cell cycle regulation and the potential implications for cancer biology.

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p19 INK4D/CDKN2D Antibody (DCS-100) References:

1. Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d).  |  Zindy, F., et al. 2001. Mol Cell Biol. 21: 3244-55. PMID: 11287627
2. p19Ink4d and p18Ink4c cyclin-dependent kinase inhibitors in the male reproductive axis.  |  Buchold, GM., et al. 2007. Mol Reprod Dev. 74: 997-1007. PMID: 17342741
3. Differential post-transcriptional regulation of two Ink4 proteins, p18 Ink4c and p19 Ink4d.  |  Forget, A., et al. 2008. Cell Cycle. 7: 3737-46. PMID: 19029828
4. Frequent loss of p19INK4D expression in hepatocellular carcinoma: relationship to tumor differentiation and patient survival.  |  Morishita, A., et al. 2011. Oncol Rep. 26: 1363-8. PMID: 21901251
5. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.  |  Hirai, H., et al. 1995. Mol Cell Biol. 15: 2672-81. PMID: 7739547
6. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.  |  Chan, FK., et al. 1995. Mol Cell Biol. 15: 2682-8. PMID: 7739548
7. Germline p16 mutations in familial melanoma.  |  Hussussian, CJ., et al. 1994. Nat Genet. 8: 15-21. PMID: 7987387
8. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.  |  Guan, KL., et al. 1994. Genes Dev. 8: 2939-52. PMID: 8001816
9. Rates of p16 (MTS1) mutations in primary tumors with 9p loss.  |  Cairns, P., et al. 1994. Science. 265: 415-7. PMID: 8023167
10. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.  |  Hannon, GJ. and Beach, D. 1994. Nature. 371: 257-61. PMID: 8078588
11. A cell cycle regulator potentially involved in genesis of many tumor types.  |  Kamb, A., et al. 1994. Science. 264: 436-40. PMID: 8153634
12. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.  |  Serrano, M., et al. 1993. Nature. 366: 704-7. PMID: 8259215

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p19 INK4D/CDKN2D Antibody (DCS-100) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-p19 INK4D/CDKN2D Antibody (DCS-100) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p19 INK4D/CDKN2D Antibody (DCS-100) Specifications

Alternate Product Name: p19 INK4D

Product Clone Name: DCS-100

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: p19 INK4D

Epitope Species: human

Product Reactivity/Detection: p19

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for p19 INK4D/CDKN2D Antibody (DCS-100): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin