p19 INK4D/CDKN2D Antibody (6A150): sc-71810

p19 INK4D Antibody (6A150) is a mouse monoclonal IgG1 antibody that detects p19 INK4D in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p19 INK4D plays a crucial role in regulating the cell cycle by specifically inhibiting the kinase activities of cyclin-dependent kinases Cdk4 and Cdk6, which are essential for the transition from the G1 phase to the S phase of the cell cycle. This inhibition helps prevent uncontrolled cell proliferation, a hallmark of cancer. p19 INK4D expression reaches maximum levels during the S phase, and overexpression can lead to G1 arrest, acting as a critical checkpoint in cellular growth and division. The gene encoding p19 INK4D is located on chromosome 9p21.3, a region frequently associated with chromosomal abnormalities in various human tumors, highlighting p19 INK4D′s potential significance in cancer research and therapeutic strategies. Through interactions with key regulatory proteins in the cell cycle, p19 INK4D serves as an important biomarker for studying cell cycle dynamics and mechanisms underlying tumorigenesis.

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p19 INK4D/CDKN2D Antibody (6A150) References:

1. p16INK4a and p19INK4d mRNA expression in neuroglial tumours: correlation with Ki67 proliferation index.  |  Bouvier-Labit, C., et al. 1999. Neuropathol Appl Neurobiol. 25: 408-16. PMID: 10564531
2. Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis.  |  Bartkova, J., et al. 2000. Oncogene. 19: 4146-50. PMID: 10962575
3. P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1.  |  Gilles, L., et al. 2008. Blood. 111: 4081-91. PMID: 18276842
4. E2F1-mediated upregulation of p19INK4d determines its periodic expression during cell cycle and regulates cellular proliferation.  |  Carcagno, AL., et al. 2011. PLoS One. 6: e21938. PMID: 21765927
5. E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation.  |  Carcagno, AL., et al. 2012. Mol Cell Biochem. 366: 123-9. PMID: 22476863
6. Expression and regulation of G1 cell-cycle inhibitors (p16INK4A, p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and normal myeloid cells.  |  Schwaller, J., et al. 1997. Leukemia. 11: 54-63. PMID: 9001419
7. NMR structural characterization of the CDK inhibitor p19INK4d.  |  Kalus, W., et al. 1997. FEBS Lett. 401: 127-32. PMID: 9013872
8. Features of macrophage differentiation induced by p19INK4d, a specific inhibitor of cyclin D-dependent kinases.  |  Adachi, M., et al. 1997. Blood. 90: 126-37. PMID: 9207446
9. Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.  |  Brotherton, DH., et al. 1998. Nature. 395: 244-50. PMID: 9751051
10. Backbone dynamics of the CDK inhibitor p19(INK4d) studied by 15N NMR relaxation experiments at two field strengths.  |  Renner, C., et al. 1998. J Mol Biol. 283: 221-9. PMID: 9761685

The preferred p19 INK4D/CDKN2D antibody is p19 INK4D/CDKN2D Antibody (DCS-100): sc-56334.