CDKN2C/p18 INK4c Antibody (DCS-118): sc-56332

p18 INK4C Antibody (DCS-118) is a mouse monoclonal IgG1 antibody that detects p18 INK4C in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p18 INK4C plays a crucial role in regulating the cell cycle by interacting with cyclin-dependent kinases, particularly Cdk6, thereby inhibiting Cdk6 activity and contributing to cell cycle arrest. p18 INK4C function is particularly important in tumor suppression, as dysregulation of cell cycle progression is a hallmark of cancer. p18 INK4C is primarily located in the nucleus, where p18 INK4C exerts effects on cell cycle regulation, and p18 INK4C expression is often altered in various malignancies, making p18 INK4C a significant focus of cancer research. The gene encoding p18 INK4C is located adjacent to the p16 INK4A gene on chromosome 9p21.3, a region frequently associated with chromosomal abnormalities in human tumors. Understanding p18 INK4C interactions and regulatory mechanisms can provide insights into potential therapeutic targets for cancer treatment and broader implications of cell cycle dysregulation in disease.

The preferred CDKN2C/p18 INK4c antibody is CDKN2C/p18 INK4c Antibody (118.2): sc-9965.