CDKN2A/p16 Antibody (F-9): sc-55600

p16 INK4A Antibody (F-9) is a mouse monoclonal IgG2a antibody that detects p16 INK4A in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p16 INK4A plays a crucial role as a negative regulator of the cell cycle, specifically inhibiting cyclin-dependent kinase 4 (Cdk4) activity, which is essential for the transition from the G1 phase to the S phase of the cell cycle. By binding to Cdk4, p16 INK4A prevents the formation of the active Cdk4/cyclin D complex, thereby halting cell proliferation and serving as a critical checkpoint in cellular growth regulation. The importance of p16 INK4A is underscored by frequent mutations and deletions in various human tumors, highlighting its role as a tumor suppressor. p16 INK4A′s ability to regulate cell cycle progression makes this protein a significant focus of research in cancer biology, as understanding p16 INK4A function and interactions can provide insights into tumorigenesis and potential therapeutic targets. With specificity for mouse samples and versatility in various applications, anti-p16 INK4A antibody (F-9) is an invaluable tool for researchers studying cell cycle regulation and cancer.

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The preferred CDKN2A/p16 antibody is CDKN2A/p16 Antibody (JC8): sc-56330.