CDKN2A/p16 Antibody (F-4): sc-74401
- CDKN2A/p16 Antibody (F-4) is a mouse monoclonal IgG1, cited in 11 publications, provided at 200 µg/ml
- raised against amino acids 1-168 representing full length p16 INK4A of mouse origin
- recommended for detection of p16 INK4A of mouse origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CDKN2A/p16 Antibody (F-4). This work is in progress.
p16 INK4A Antibody (F-4) is a mouse monoclonal IgG1 antibody that detects p16 INK4A in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p16 INK4A plays a crucial role as a negative regulator of the cell cycle, specifically inhibiting cyclin-dependent kinase 4 (Cdk4) activity, which is essential for the transition from the G1 phase to the S phase of the cell cycle. By binding to Cdk4, p16 INK4A prevents the formation of the active Cdk4/cyclin D complex, thereby halting cell proliferation and maintaining cellular integrity. This regulatory function is particularly important in the context of tumor suppression, as the loss or mutation of p16 INK4A is frequently observed in various human cancers, leading to uncontrolled cell division. The ability of p16 INK4A to modulate cell cycle progression underscores its significance in cancer biology and highlights anti-p16 INK4A antibody (F-4) as a valuable tool for research into cell cycle regulation and tumorigenesis.
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CDKN2A/p16 Antibody (F-4) References:
- Differential expression of p16(INK4a) in azoxymethane-induced mouse colon tumorigenesis. | Wang, QS., et al. 2000. Mol Carcinog. 28: 139-47. PMID: 10942530
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDKN2A/p16 Antibody (F-4) | sc-74401 | 200 µg/ml | $322.00 |