CDKN2A/p16 Antibody (DCS-50): sc-65476
- CDKN2A/p16 Antibody (DCS-50) is a mouse monoclonal IgG1, cited in 9 publications, provided at 200 µg/ml
- raised against full length p16 INK4A of human origin
- recommended for detection of p16 INK4A of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CDKN2A/p16 Antibody (DCS-50) for WB and IHC(P) applications. These reagents are now offered in bundles with CDKN2A/p16 Antibody (DCS-50) (see ordering information below).
p16 INK4A Antibody (DCS-50) is a mouse monoclonal IgG1 antibody that detects p16 INK4A in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p16 INK4A plays a crucial role as a tumor suppressor by inhibiting cyclin-dependent kinase 4 (Cdk4), thereby preventing the phosphorylation of the retinoblastoma protein (Rb) and blocking cell cycle progression from the G1 phase to the S phase. This function is vital for maintaining proper cell cycle regulation and preventing uncontrolled cell proliferation, which is a hallmark of cancer. Notably, the gene encoding p16 INK4A is frequently altered in various human tumors, with homozygous deletions and point mutations being common, underscoring p16 INK4A′s importance in cancer biology. Anti-p16 INK4A antibody (DCS-50) is an essential tool for researchers studying cell cycle regulation and the molecular mechanisms underlying tumorigenesis, providing insights into potential therapeutic targets for cancer treatment.
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDKN2A/p16 Antibody (DCS-50) | sc-65476 | 200 µg/ml | $322.00 | |||
CDKN2A/p16INK4a Antibody (DCS-50): m-IgG Fc BP-HRP Bundle | sc-539174 | 200 µg Ab; 10 µg BP | $361.00 | |||
CDKN2A/p16INK4a Antibody (DCS-50): m-IgG1 BP-HRP Bundle | sc-541310 | 200 µg Ab; 20 µg BP | $361.00 |