CDKN2A/p16 Antibody (A-6): sc-390485
- CDKN2A/p16 Antibody (A-6) is a mouse monoclonal IgG1, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 1-156 of p16 INK4A of human origin
- recommended for detection of p16 INK4A and, to a lesser extent, p15 INK4B and p18 INK4C of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CDKN2A/p16 Antibody (A-6). This work is in progress.
p16 INK4A Antibody (A-6) is a mouse monoclonal IgG1 antibody that detects p16 INK4A in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p16 INK4A plays a crucial role as a negative regulator of the cell cycle, specifically inhibiting cyclin-dependent kinase 4 (Cdk4) activity, which is essential for the transition from the G1 phase to the S phase of the cell cycle. By binding to Cdk4, p16 INK4A prevents the formation of the active Cdk4/cyclin D complex, thereby halting cell proliferation and serving as a critical checkpoint in cellular growth regulation. The importance of p16 INK4A is underscored by frequent mutations and deletions in various human tumors, highlighting p16 INK4A′s role as a tumor suppressor. p16 INK4A′s ability to regulate cell cycle progression makes anti-p16 INK4A antibody (A-6) a significant focus of research in cancer biology, as understanding p16 INK4A function and interactions can provide insights into tumorigenesis and potential therapeutic targets. With specificity for human samples and versatility in multiple applications, anti-p16 INK4A antibody (A-6) serves as an invaluable tool for researchers studying cell cycle regulation and cancer development.
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDKN2A/p16 Antibody (A-6) | sc-390485 | 200 µg/ml | $322.00 |