CDKN2A/p16 Antibody (2D9A12): sc-81157

p16 INK4A Antibody (2D9A12) is a mouse monoclonal IgG1 antibody that detects p16 INK4A in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. p16 INK4A plays a crucial role as a negative regulator of the cell cycle, specifically inhibiting cyclin-dependent kinase 4 (Cdk4) activity, which is essential for the transition from the G1 phase to the S phase of the cell cycle. By binding to Cdk4, p16 INK4A prevents the formation of the active Cdk4/cyclin D complex, thereby halting cell proliferation and maintaining cellular integrity. This regulatory function is particularly important in the context of tumor suppression, as the gene encoding p16 INK4A is frequently altered in various cancers, with homozygous deletions and point mutations observed in established human tumor cell lines. The ability of p16 INK4A to modulate cell cycle progression underscores its significance in cancer biology, making anti-p16 INK4A antibody (2D9A12) an invaluable tool for researchers investigating cell cycle regulation and tumorigenesis.

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The preferred CDKN2A/p16 antibody is CDKN2A/p16 Antibody (JC8): sc-56330.