p150 Antibody (JK-13): sc-100798

p150 Antibody (JK-13) is a mouse monoclonal IgG2a kappa light chain antibody that detects p150 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-p150 antibody (JK-13) is available as the non-conjugated form. p150 protein plays a crucial role in cellular sorting and delivery of proteins to appropriate organelles, which is vital for maintaining normal cellular functions. Specifically, p150 is the human homolog of yeast Vps15p protein, which is integral to the protein trafficking system that transports vacuolar proteins from Golgi network to the vacuole, where proteins undergo essential post-translational modifications. The interaction between p150 and Vps34p, a key component of this system, is particularly important as Vps34p is regulated by Vps15p and shares homology with proteins in the phosphoinositide 3-kinase family. This regulation is critical for enhancing Vps34p′s kinase activity and ensuring proper membrane recruitment at Golgi complex. Additionally, p150 is subject to post-translational modifications, including myristoylation, which can influence function and interactions within the cell. With broad expression across human tissues, p150 monoclonal antibody (JK-13) serves as an essential tool for researchers studying protein trafficking and cellular organization.

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p150 Antibody (JK-13) References:

1. Protein targeting to the yeast vacuole.  |  Rothman, JH., et al. 1989. Trends Biochem Sci. 14: 347-50. PMID: 2529676
2. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.  |  Volinia, S., et al. 1995. EMBO J. 14: 3339-48. PMID: 7628435
3. Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast.  |  Stack, JH., et al. 1995. J Cell Biol. 129: 321-34. PMID: 7721937
4. Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.  |  Stack, JH. and Emr, SD. 1994. J Biol Chem. 269: 31552-62. PMID: 7989323
5. Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteins.  |  Stack, JH., et al. 1995. Annu Rev Cell Dev Biol. 11: 1-33. PMID: 8689553
6. Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex.  |  Panaretou, C., et al. 1997. J Biol Chem. 272: 2477-85. PMID: 8999962

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p150 Antibody (JK-13) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-p150 Antibody (JK-13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p150 Antibody (JK-13) Specifications

Alternate Product Name: p150

Product Clone Name: JK-13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1259-1359

Epitope Target: p150

Epitope Species: human

Product Reactivity/Detection: p150

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for p150 Antibody (JK-13): N/A

The preferred p150 antibody is p150 Antibody (F-7): sc-518227.