p-Stat3 Antibody (23G5): sc-56747

p-Stat3 Antibody (23G5) is a mouse monoclonal IgG1 antibody that detects p-Stat3 in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-Stat3 is a critical component of signaling pathways activated by various cytokines, particularly interleukin-6 (IL-6) and growth factors, which play a vital role in regulating immune responses, cell growth, and differentiation. This activation occurs in response to extracellular signals binding to receptors such as gp130 and Janus kinases (JAKs), which phosphorylate Stat3 at tyrosine 705. Once phosphorylated, p-Stat3 dimerizes and translocates to the nucleus to regulate target gene expression, including genes involved in cell survival, proliferation, and angiogenesis. Additionally, p-Stat3 is integral to the modulation of inflammatory responses, influencing the production of cytokines and acute-phase proteins. Dysregulation of p-Stat3 signaling has been linked not only to oncogenesis but also to autoimmune disorders and chronic inflammatory diseases, highlighting its wide-ranging impact on cellular function. Understanding the mechanisms governing p-Stat3 activation and inhibition is critical for elucidating its role in pathological and physiological processes. Anti-p-Stat3 antibody (23G5) provides researchers with a reliable tool for studying the dynamics of Stat3 activation and its downstream effects in various biological contexts, thereby contributing to a deeper understanding of its role in health and disease.

The preferred p-Stat3 antibody is p-Stat3 Antibody (B-7): sc-8059.