p-RUNX1 Antibody (12.Ser 249): sc-293146

p-RUNX1 Antibody (12.Ser 249) is a mouse monoclonal IgG1 antibody that detects RUNX1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). RUNX1, a member of the Runt-related transcription factor family, plays a crucial role in regulating gene expression related to cellular differentiation and cell cycle progression, making RUNX1 vital for processes such as hematopoiesis and sensory neuron diversification. RUNX1 is primarily located in the nucleus, where RUNX1 binds to DNA and influences transcription of target genes. Nuclear localization enables RUNX1 to interact with various transcriptional co-factors and chromatin remodeling complexes, thereby modulating gene expression in response to developmental cues. Additionally, RUNX1 undergoes post-translational modifications, including phosphorylation at Serine 249, which can affect stability and activity, further underscoring the importance of these modifications in regulating function in both normal physiology and disease states, such as leukemia. p-RUNX1 (12.Ser 249) antibody serves as an invaluable tool for researchers studying the intricate roles of RUNX1 in cellular processes and implications in various pathologies.

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p-RUNX1 Antibody (12.Ser 249) References:

1. Oncogenic potential of the RUNX gene family: 'overview'.  |  Ito, Y. 2004. Oncogene. 23: 4198-208. PMID: 15156173
2. Role of RUNX family members in transcriptional repression and gene silencing.  |  Durst, KL. and Hiebert, SW. 2004. Oncogene. 23: 4220-4. PMID: 15156176
3. Leukaemia/Drosophila homology.  |  Daga, A., et al. 1992. Nature. 356: 484. PMID: 1560822
4. Role of Runx proteins in chondrogenesis.  |  Yoshida, CA. and Komori, T. 2005. Crit Rev Eukaryot Gene Expr. 15: 243-54. PMID: 16390320
5. The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons.  |  Marmigère, F., et al. 2006. Nat Neurosci. 9: 180-7. PMID: 16429136
6. A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification.  |  Kramer, I., et al. 2006. Neuron. 49: 379-93. PMID: 16446142
7. Combination of RUNX1 inhibitor and gemcitabine mitigates chemo-resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress.  |  She, C., et al. 2023. J Exp Clin Cancer Res. 42: 238. PMID: 37697370
8. Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia.  |  Miyoshi, H., et al. 1995. Nucleic Acids Res. 23: 2762-9. PMID: 7651838
9. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.  |  Golub, TR., et al. 1995. Proc Natl Acad Sci U S A. 92: 4917-21. PMID: 7761424
10. A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1.  |  Levanon, D., et al. 1996. DNA Cell Biol. 15: 175-85. PMID: 8634147
11. Leukemogenesis by the chromosomal translocations.  |  Mitani, K. 1997. Leukemia. 11 Suppl 3: 294-6. PMID: 9209370
12. Role of histone deacetylases in acute leukemia.  |  Fenrick, R. and Hiebert, SW. 1998. J Cell Biochem Suppl. 30-31: 194-202. PMID: 9893271

The preferred RUNX1 antibody is RUNX1 Antibody (A-2): sc-365644.