p-Ribosomal Protein S6 Antibody (B-6): sc-514033

p-Ribosomal Protein S6 Antibody (B-6) is a mouse monoclonal IgM antibody that detects p-Ribosomal Protein S6 (RPS6) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p-Ribosomal Protein S6 (B-6) antibody is available in a non-conjugated form, providing flexibility for various experimental needs. RPS6 encodes Ribosomal Protein S6, which plays a crucial role in protein synthesis and cell growth regulation. RPS6 is primarily located in ribosomes, where RPS6 is essential for ribosomal subunit assembly and mRNA translation into proteins. RPS6 localization within ribosomes underscores RPS6′s importance in cellular function, as RPS6 directly influences protein synthesis efficiency, vital for cell proliferation and response to growth signals. RPS6 serves as a major substrate for several protein kinases, and RPS6 phosphorylation is tightly regulated by growth factors and mitogens, making RPS6 a key player in signaling pathways that control cell growth and metabolism. RPS6 evolutionary conservation across species, from yeast to humans, highlights RPS6′s fundamental role in cellular biology and potential as a target for therapeutic interventions in diseases characterized by dysregulated protein synthesis.

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p-Ribosomal Protein S6 Antibody (B-6) References:

1. Identification of the S6 kinase activity stimulated in quiescent brine shrimp embryos upon entry to preemergence development as p70 ribosomal protein S6 kinase: isolation of Artemia franciscana p70S6k cDNA.  |  Santiago, J. and Sturgill, TW. 2001. Biochem Cell Biol. 79: 141-52. PMID: 11310561
2. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms.  |  Gong, Y., et al. 2007. J Biol Chem. 282: 31019-27. PMID: 17726024
3. Baculovirus-mediated expression, purification, and characterization of a fully activated catalytic kinase domain construct of the 70 kDa 40S ribosomal protein S6 kinase-1 alphaII isoform (S6K1alphaII).  |  Keshwani, MM., et al. 2008. Protein Expr Purif. 58: 32-41. PMID: 18160308
4. Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma.  |  Kim, SH., et al. 2013. Mod Pathol. 26: 327-35. PMID: 22996377
5. Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells.  |  Wittenberg, AD., et al. 2016. PLoS One. 11: e0149995. PMID: 26919188
6. Phosphorylated ribosomal protein S6 correlation with p21 expression and inverse association with tumor size in oral squamous cell carcinoma.  |  de Vicente, JC., et al. 2017. Head Neck. 39: 1876-1887. PMID: 28675642
7. Effect of IL-7 Therapy on Phospho-Ribosomal Protein S6 and TRAF1 Expression in HIV-Specific CD8 T Cells in Patients Receiving Antiretroviral Therapy.  |  Wang, C., et al. 2018. J Immunol. 200: 558-564. PMID: 29222166
8. Ribosomal Protein S6 Hypofunction in Postmortem Human Brain Links mTORC1-Dependent Signaling and Schizophrenia.  |  Ibarra-Lecue, I., et al. 2020. Front Pharmacol. 11: 344. PMID: 32265715
9. Expression of phosphorylated ribosomal protein S6 in mesothelioma patients - correlation with clinico-pathological characteristics and outcome: results from the European Thoracic Oncology Platform (ETOP) Mesoscape project.  |  Rüschoff, JH., et al. 2022. Mod Pathol. 35: 1888-1899. PMID: 36115922
10. Investigating the Regulation of Ribosomal Protein S6 Kinase 1 by CoAlation.  |  Malanchuk, O., et al. 2024. Int J Mol Sci. 25: PMID: 39201434

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Ribosomal Protein S6 Antibody (B-6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Ribosomal Protein S6 Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Ribosomal Protein S6 Antibody (B-6) Specifications

Alternate Product Name: RPS6

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: Ser 236

Epitope Target: Ribosomal Protein S6

Epitope Species: human

Product Reactivity/Detection: Ser 236 phosphorylated 40S Ribosomal Protein S6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for p-Ribosomal Protein S6 Antibody (B-6): P: Blocking Peptide

The preferred Ribosomal Protein S6 antibody is Ribosomal Protein S6 Antibody (C-8): sc-74459.