P/Q-type Ca++ CP α1A Antibody (C-2): sc-390004
- P/Q-type Ca++ CP α1A Antibody (C-2) is a mouse monoclonal IgG1 κ P/Q-type Ca++ CP α1A antibody provided at 200 µg/ml
- raised against amino acids 2225-2314 mapping within a cytoplasmic domain of P/Q-type Ca++ CP α1A of human origin
- P/Q-type Ca++ CP alpha 1A Antibody (C-2) is recommended for detection of P/Q-type Ca++ CP α1A of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-P/Q-type Ca++ CP alpha 1A Antibody (C-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for P/Q-type Ca++ CP α1A Antibody (C-2) for WB applications. This reagent is now offered in a bundle with P/Q-type Ca++ CP α1A Antibody (C-2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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P/Q-type Ca++ CP α1A Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects P/Q-type Ca++ CP alpha 1A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). P/Q-type Ca++ CP α1A (C-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. P/Q-type Ca++ CP alpha 1A protein plays a critical role in voltage-dependent calcium channels, which are essential for mediating calcium entry into excitable cells in response to membrane depolarization. These channels are integral to numerous calcium-dependent processes, such as muscle contraction, hormone and neurotransmitter release, and gene expression. P/Q-type channels are particularly important as these are localized to presynaptic nerve terminals, facilitating rapid synaptic transmission that is finely regulated through interactions with G proteins, SNARE proteins, and various post-translational modifications. An intricate structure including an α-1 subunit, an intracellular β subunit, a disulfide-linked α-2/δ subunit, and a transmembrane γ subunit underscores functional diversity and importance in neuronal signaling.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
P/Q-type Ca++ CP α1A Antibody (C-2) References:
- A novel nonsense mutation in CACNA1A causes episodic ataxia and hemiplegia. | Jen, J., et al. 1999. Neurology. 53: 34-7. PMID: 10408533
- Interactions of presynaptic Ca2+ channels and snare proteins in neurotransmitter release. | Catterall, WA. 1999. Ann N Y Acad Sci. 868: 144-59. PMID: 10414292
- Structure and regulation of voltage-gated Ca2+ channels. | Catterall, WA. 2000. Annu Rev Cell Dev Biol. 16: 521-55. PMID: 11031246
- CaV2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis. | Uchitel, OD., et al. 2012. J Physiol Paris. 106: 12-22. PMID: 22074995
- Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction. | Niimi, K., et al. 2014. Behav Brain Res. 259: 45-9. PMID: 24177210
- Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation. | Berecki, G., et al. 2014. J Gen Physiol. 143: 465-79. PMID: 24688019
- Functional Characterization of Four Known Cav2.1 Variants Associated with Neurodevelopmental Disorders. | Folacci, M., et al. 2023. Membranes (Basel). 13: PMID: 36676903
- Molecular biology of calcium channels. | Perez-Reyes, E. and Schneider, T. 1995. Kidney Int. 48: 1111-24. PMID: 8569073
- Episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6) due to CAG repeat expansion in the CACNA1A gene on chromosome 19p. | Jodice, C., et al. 1997. Hum Mol Genet. 6: 1973-8. PMID: 9302278
- The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T? | Randall, AD. 1998. J Membr Biol. 161: 207-13. PMID: 9493126
- Recurrence of the T666M calcium channel CACNA1A gene mutation in familial hemiplegic migraine with progressive cerebellar ataxia. | Ducros, A., et al. 1999. Am J Hum Genet. 64: 89-98. PMID: 9915947
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
P/Q-type Ca++ CP α1A Antibody (C-2) | sc-390004 | 200 µg/ml | $322.00 | |||
P/Q-type Ca++ CP α1A Antibody (C-2): m-IgGκ BP-HRP Bundle | sc-523367 | 200 µg Ab, 40 µg BP | $361.00 | |||
P/Q-type Ca++ CP α1A Antibody (C-2) AC | sc-390004 AC | 500 µg/ml, 25% agarose | $424.00 | |||
P/Q-type Ca++ CP α1A Antibody (C-2) HRP | sc-390004 HRP | 200 µg/ml | $322.00 | |||
P/Q-type Ca++ CP α1A Antibody (C-2) FITC | sc-390004 FITC | 200 µg/ml | $336.00 | |||
P/Q-type Ca++ CP α1A Antibody (C-2) PE | sc-390004 PE | 200 µg/ml | $349.00 | |||
P/Q-type Ca++ CP α1A Antibody (C-2) Alexa Fluor® 488 | sc-390004 AF488 | 200 µg/ml | $364.00 | |||
P/Q-type Ca++ CP α1A Antibody (C-2) Alexa Fluor® 546 | sc-390004 AF546 | 200 µg/ml | $364.00 | |||
P/Q-type Ca++ CP α1A Antibody (C-2) Alexa Fluor® 594 | sc-390004 AF594 | 200 µg/ml | $364.00 | |||
P/Q-type Ca++ CP α1A Antibody (C-2) Alexa Fluor® 647 | sc-390004 AF647 | 200 µg/ml | $364.00 | |||
P/Q-type Ca++ CP α1A Antibody (C-2) Alexa Fluor® 680 | sc-390004 AF680 | 200 µg/ml | $364.00 | |||
P/Q-type Ca++ CP α1A Antibody (C-2) Alexa Fluor® 790 | sc-390004 AF790 | 200 µg/ml | $364.00 |