p-PKC theta Antibody (pT538.19): sc-136017
- p-PKC theta Antibody (pT538.19) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against a short amino acid sequence containing phosphorylated Thr 538 of PKC θ of human origin
- recommended for detection of Thr 538 phosphorylated PKC θ of mouse, rat and human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-PKC theta Antibody (pT538.19). This work is in progress.
p-PKC θ Antibody (pT538.19) is a mouse monoclonal IgG2a antibody that detects p-PKC θ in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. p-PKC θ, a member of the protein kinase C (PKC) family, plays a pivotal role in regulating numerous cellular processes such as cell growth, differentiation, and immune responses. p-PKC θ is primarily located in the cytoplasm and translocates to the membrane upon activation, which is crucial for function in signal transduction pathways. Membrane localization of p-PKC θ is essential for interaction with various substrates and signaling molecules, thereby influencing downstream effects such as gene expression and cellular proliferation. p-PKC θ is involved in T cell receptor signaling and has been implicated in the regulation of NFκB, a key transcription factor in immune responses. Phosphorylation of specific residues, including threonine 538, is critical for activation and subsequent cellular functions. Anti-p-PKC θ antibody (pT538.19) enables researchers to gain insights into the regulatory mechanisms of PKC θ and its role in various physiological and pathological processes.
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p-PKC theta Antibody (pT538.19) References:
- Interleukin-1β-induced barrier dysfunction is signaled through PKC-θ in human brain microvascular endothelium. | Rigor, RR., et al. 2012. Am J Physiol Cell Physiol. 302: C1513-22. PMID: 22403784
- Regulation of PKC-θ function by phosphorylation in T cell receptor signaling. | Wang, X., et al. 2012. Front Immunol. 3: 197. PMID: 22798961
- Inhibition of PKC-θ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy. | Li, Z., et al. 2014. Br J Pharmacol. 171: 2913-24. PMID: 24641494
- IFNα signaling through PKC-θ is essential for antitumor NK cell function. | Comet, NR., et al. 2014. Oncoimmunology. 3: e948705. PMID: 25960930
- PKC-θ is a negative regulator of TRAIL-induced and FADD-mediated apoptotic spectrin aggregation. | Michalczyk, I., et al. 2016. Folia Histochem Cytobiol. 54: 1-13. PMID: 27094638
- Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation. | Li, J., et al. 2016. J Cell Sci. 129: 2448-61. PMID: 27149922
- Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity. | Zanin-Zhorov, A., et al. 2017. Sci Rep. 7: 4258. PMID: 28652577
- Mice lacking PKC-θ in skeletal muscle have reduced intramyocellular lipid accumulation and increased insulin responsiveness in skeletal muscle. | Peck, B., et al. 2018. Am J Physiol Regul Integr Comp Physiol. 314: R468-R477. PMID: 29187383
- Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity. | Ben-Shmuel, A., et al. 2022. Elife. 11: PMID: 35258455
- PKC-θ is an important driver of fluoride-induced immune imbalance of regulatory T cells/effector T cells. | Zhu, S., et al. 2024. Sci Total Environ. 934: 173081. PMID: 38754514
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-PKC theta Antibody (pT538.19) | sc-136017 | 200 µg/ml | $322.00 |