p-RELA/NFκB p65 Antibody (49.Ser 311): sc-135769

p-NFκB p65 Antibody (49.Ser 311) is a mouse monoclonal IgG2a kappa light chain antibody that detects phosphorylated NFκB p65 in mouse, rat, and human samples by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-p-NFκB p65 antibody (49.Ser 311) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. NFκB p65 plays a crucial role in regulating immune responses, cell proliferation, and survival, making NFκB p65 a key player in inflammatory processes and cancer development. Phosphorylation of NFκB p65 at Serine-311, specifically induced by protein kinase C ζ, is essential for transcriptional activity and nuclear localization, which further underscores NFκB p65′s importance in cellular signaling pathways. NFκB complex, which includes p65, binds to specific DNA sequences, thereby influencing gene expression involved in immune and inflammatory responses. Understanding the dynamics of NFκB p65 phosphorylation and interactions with other proteins can provide insights into therapeutic targets for diseases characterized by dysregulated NFκB signaling. p-NFκB p65 monoclonal antibody (49.Ser 311) serves as an essential tool for studying NFκB p65 phosphorylation at Serine-311, shedding light on NFκB p65′s role in transcriptional regulation and impact on cellular signaling pathways.

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p-RELA/NFκB p65 Antibody (49.Ser 311) References:

1. Inhibitor of growth 4 induces NFκB/p65 ubiquitin-dependent degradation.  |  Hou, Y., et al. 2014. Oncogene. 33: 1997-2003. PMID: 23624912
2. Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury.  |  Wang, L., et al. 2018. Cell Physiol Biochem. 50: 1535-1559. PMID: 30376671
3. ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.  |  Lai, X., et al. 2021. J Hazard Mater. 410: 124566. PMID: 33323305
4. Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury.  |  Liu, C., et al. 2022. J Nanobiotechnology. 20: 65. PMID: 35109874
5. AQP2 Promotes Astrocyte Activation by Modulating the TLR4/NFκB-p65 Pathway Following Intracerebral Hemorrhage.  |  Deng, S., et al. 2022. Front Immunol. 13: 847360. PMID: 35386692
6. Complement C3 mediates podocyte injury through TLR4/NFΚB-P65 signaling during ischemia-reperfusion acute kidney injury and post-injury fibrosis.  |  Chen, Y., et al. 2023. Eur J Med Res. 28: 135. PMID: 36973754
7. Disruption of Histamine-H1R signaling exacerbates cardiac microthrombosis after periodontal disease via TLR4/NFκB-p65 pathway.  |  Yang, X., et al. 2023. Int Immunopharmacol. 123: 110774. PMID: 37567012
8. SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer.  |  Lin, C., et al. 2023. Oncogenesis. 12: 41. PMID: 37573425
9. Lead exposure induces neuronal apoptosis via NFκB p65/RBBP4/Survivin signaling pathway.  |  Chen, H., et al. 2023. Toxicology. 499: 153654. PMID: 37866543
10. Tumor Inflammatory Microenvironment of the Thyroid Cancer: Relationship between Regulatory T-Cell Imbalance, and p-NFΚB (p65) Expression-A Preliminary Study.  |  Pasquali, D., et al. 2023. J Clin Med. 12: PMID: 37959281

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-RELA/NFκB p65 Antibody (49.Ser 311) has 29 citations in a variety of scientific publications.

Primary antibodies like Anti-p-RELA/NFκB p65 Antibody (49.Ser 311) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-RELA/NFκB p65 Antibody (49.Ser 311) Specifications

Alternate Product Name: RELA, RelA, p65, NFKB3

Product Clone Name: 49.Ser 311

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: Ser 311

Epitope Target: NFκB p65

Epitope Species: human

Product Reactivity/Detection: Ser 311 phosphorylated NFκB p65

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 29 citations in various scientific publications

Available Conjugates/Forms for p-RELA/NFκB p65 Antibody (49.Ser 311): AC: Agarose, HRP: Horseradish Peroxidase, X: TransCruz Reagent

The preferred RELA/NFκB p65 antibody is RELA/NFκB p65 Antibody (F-6): sc-8008.