p-ErbB2/HER2 Antibody (7F8): sc-81508

p-Neu Antibody (7F8) is a mouse monoclonal IgG1 antibody that detects Neu in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-Neu (7F8) antibody specifically recognizes phosphorylated forms of Neu, which is crucial for understanding Neu′s role in various signaling pathways associated with cancer progression. Neu, also known as HER2, is a member of the ErbB family of receptor tyrosine kinases and plays a significant role in cell growth and differentiation. Neu is primarily located at the cell membrane, where Neu interacts with other receptors and signaling molecules, facilitating the transduction of extracellular signals that promote cellular proliferation and survival. This localization allows Neu to participate in critical processes such as tissue development and repair, and Neu dysregulation is implicated in the etiology of several aggressive cancers, including breast and gastric cancers. The phosphorylation of Neu at specific tyrosine residues, such as Tyr 1248, is essential for Neu interaction with downstream signaling proteins like GRB2 and Shc, which further propagate the signaling cascade. Using anti-Neu antibody (7F8) in research can provide insights into the mechanisms of Neu-mediated signaling and oncogenesis implications, making anti-Neu antibody (7F8) an invaluable tool for cancer research and therapeutic development.

The preferred antibody is Antibody (): sc-8.