p-HMGN3 Antibody (47.Ser 31): sc-135764

p-HMGN3 Antibody (47.Ser 31) is a mouse monoclonal IgG2a kappa light chain antibody that detects Ser 31 phosphorylated HMGN3 of mouse, rat, and human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). p-HMGN3 (47.Ser 31) antibody is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. HMGN3, also known as high mobility group nucleosome-binding domain-containing protein 3 or thyroid receptor-interacting protein 7, is a 99 amino acid protein that plays a crucial role in chromatin dynamics. Localized primarily in the nucleus, HMGN3 is essential for enhancing transcription from chromatin templates by reducing the compactness of chromatin fibers within nucleosomes, thereby facilitating access for transcription factors and other regulatory proteins. This function is particularly important in the regulation of gene expression, as HMGN3 allows for precise control of cellular responses to various stimuli, including hormonal signals. HMGN3 is induced by estrogen and is predominantly expressed in skeletal muscle, kidney, and heart, with lower expression levels in the liver, pancreas, and lung. Additionally, HMGN3 exists in two isoforms generated through alternative splicing, which may contribute to functional diversity in different tissues. anti-HMGN3 antibody (47.Ser 31) specifically recognizes phosphorylated HMGN3, making p-HMGN3 (47.Ser 31) monoclonal antibody a valuable tool for studying regulatory mechanisms of gene expression and the role of post-translational modifications in cellular processes.

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p-HMGN3 Antibody (47.Ser 31) References:

1. HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome-binding proteins.  |  West, KL., et al. 2001. J Biol Chem. 276: 25959-69. PMID: 11356838
2. Differential display RT-PCR analysis of enterovirus-71-infected rhabdomyosarcoma cells reveals mRNA expression responses of multiple human genes with known and novel functions.  |  Leong, PW., et al. 2002. Virology. 295: 147-59. PMID: 12033773
3. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.  |  Wu, C., et al. 2007. Proteomics. 7: 1775-85. PMID: 17474147
4. Cell cycle-dependent binding of HMGN proteins to chromatin.  |  Cherukuri, S., et al. 2008. Mol Biol Cell. 19: 1816-24. PMID: 18287527
5. Differential expression of the HMGN family of chromatin proteins during ocular development.  |  Lucey, MM., et al. 2008. Gene Expr Patterns. 8: 433-437. PMID: 18502697
6. The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion.  |  Ueda, T., et al. 2009. Mol Cell Biol. 29: 5264-76. PMID: 19651901
7. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.  |  Lee, JW., et al. 1995. Mol Endocrinol. 9: 243-54. PMID: 7776974

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-HMGN3 Antibody (47.Ser 31) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-p-HMGN3 Antibody (47.Ser 31) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-HMGN3 Antibody (47.Ser 31) Specifications

Alternate Product Name: HMGN3

Product Clone Name: 47.Ser 31

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: Ser 31

Epitope Target: HMGN3

Epitope Species: human

Product Reactivity/Detection: Ser 31 phosphorylated HMGN3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for p-HMGN3 Antibody (47.Ser 31): AC: Agarose, HRP: Horseradish Peroxidase, X: TransCruz Reagent