p-GSK-3α Antibody (9B8): sc-81497
- p-GSK-3α Antibody (9B8) is a mouse monoclonal IgG1, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against phosphopeptide corresponding to amino acid residues surrounding serine 21 of GSK-3α of human origin
- recommended for detection of Ser 21 phosphorylated GSK-3α of mouse, rat, human and canine origin by WB, IP and IF; non cross-reactive with the homologous phosphorylation site in GSK-3β
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-GSK-3α Antibody (9B8). This work is in progress.
p-GSK-3α Antibody (9B8) is a mouse monoclonal IgG1 antibody that detects glycogen synthase kinase-3α (GSK-3α) in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). anti-GSK-3α antibody (9B8) specifically recognizes the phosphorylated form of GSK-3α, which plays a crucial role in various cellular processes, including energy metabolism and neuronal cell development. GSK-3α (9B8) antibody targets proteins primarily located in the cytoplasm and nucleus, where GSK-3α regulates key signaling pathways that influence cell growth and survival. GSK-3α′s localization enables interaction with various substrates and signaling molecules, modulating their activity in response to extracellular signals. Nuclear presence of GSK-3α is essential for transcriptional regulation, particularly in cell proliferation and differentiation. Growth factors can influence GSK-3α′s phosphorylation state, which determines activity and protein interactions, highlighting the importance of cellular location in maintaining proper function. GSK-3α monoclonal antibody (9B8) provides valuable insights into regulatory mechanisms, making this antibody an invaluable tool for researchers studying metabolic pathways and signaling cascades in various biological contexts.
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p-GSK-3α Antibody (9B8) References:
- Varicella-zoster virus requires a functional PI3K/Akt/GSK-3alpha/beta signaling cascade for efficient replication. | Rahaus, M., et al. 2007. Cell Signal. 19: 312-20. PMID: 16934436
- Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. | Matsuda, T., et al. 2008. Proc Natl Acad Sci U S A. 105: 20900-5. PMID: 19106302
- Distinct expression and activity of GSK-3α and GSK-3β in prostate cancer. | Darrington, RS., et al. 2012. Int J Cancer. 131: E872-83. PMID: 22539113
- GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation. | Itoh, S., et al. 2012. J Biol Chem. 287: 29227-36. PMID: 22761446
- Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload. | Maejima, Y., et al. 2012. Am J Physiol Heart Circ Physiol. 303: H979-88. PMID: 22904158
- GSK-3α/β-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth. | Tan, M., et al. 2013. J Neurochem. 125: 685-97. PMID: 23470087
- [Expression of pGSK-3α/β Tyr279/216 and XIAP proteins in cholangiocarcinoma and their clinical significance]. | Xu, JW., et al. 2013. Zhonghua Zhong Liu Za Zhi. 35: 366-71. PMID: 24054014
- Inositol synthesis regulates the activation of GSK-3α in neuronal cells. | Ye, C. and Greenberg, ML. 2015. J Neurochem. 133: 273-83. PMID: 25345501
- Role of PKB/SGK-dependent phosphorylation of GSK-3α/β in vascular calcification during cholecalciferol overload in mice. | Tuffaha, R., et al. 2018. Biochem Biophys Res Commun. 503: 2068-2074. PMID: 30119888
- GSK-3α/β Activity Negatively Regulates MMP-1/9 Expression to Suppress Mycobacterium tuberculosis Infection. | Zhou, X., et al. 2021. Front Immunol. 12: 752466. PMID: 35095838
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-GSK-3α Antibody (9B8) | sc-81497 | 50 µg/0.5 ml | $322.00 |