p-CD130/gp130 Antibody (A-12): sc-377572
- p-CD130/gp130 Antibody (A-12) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids Ser 782 Ser 782 of gp130 of human origin
- Anti-p-CD130/gp130 Antibody (A-12) is recommended for detection of Ser 782 phosphorylated gp130 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine
- Anti-p-CD130/gp130 Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP is the preferred secondary detection reagent for p-CD130/gp130 Antibody (A-12) for WB and IHC(P) applications. This reagent is now offered in a bundle with p-CD130/gp130 Antibody (A-12) (see ordering information below).
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p-gp130 Antibody (A-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects phosphorylated gp130 (p-gp130) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p-gp130 (A-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. gp130 plays a crucial role in signaling pathways activated by interleukin-6 (IL-6) and related cytokines, functioning as a common signal transducer for several receptor complexes. gp130′s ability to form a dimer with another gp130 molecule upon IL-6 receptor activation is essential for initiating downstream signaling cascades that regulate various biological processes, including inflammation, immune response, and hematopoiesis. Notably, phosphorylation of Ser 782, located near the di-leucine motif of gp130, is critical for modulating receptor internalization and cell surface expression, thereby influencing the intensity and duration of signaling response. anti-p-gp130 antibody (A-12) serves as an invaluable tool for researchers studying cytokine signaling mechanisms and their implications in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p-CD130/gp130 Antibody (A-12) References:
- Phosphorylation of human gp130 at Ser-782 adjacent to the Di-leucine internalization motif. Effects on expression and signaling. | Gibson, RM., et al. 2000. J Biol Chem. 275: 22574-82. PMID: 10811661
- Survival pathways in hypertrophy and heart failure: the gp130-STAT axis. | Fischer, P. and Hilfiker-Kleiner, D. 2007. Basic Res Cardiol. 102: 393-411. PMID: 17918316
- Molecular cloning and expression of an IL-6 signal transducer, gp130. | Hibi, M., et al. 1990. Cell. 63: 1149-57. PMID: 2261637
- Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. | Taga, T., et al. 1989. Cell. 58: 573-81. PMID: 2788034
- Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. | Yamasaki, K., et al. 1988. Science. 241: 825-8. PMID: 3136546
- Langat virus inhibits the gp130/JAK/STAT signaling by reducing the gp130 protein level. | Lin, S., et al. 2024. J Med Virol. 96: e29522. PMID: 38533889
- LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. | Davis, S., et al. 1993. Science. 260: 1805-8. PMID: 8390097
- IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. | Murakami, M., et al. 1993. Science. 260: 1808-10. PMID: 8511589
- Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development. | Wollert, KC. and Chien, KR. 1997. J Mol Med (Berl). 75: 492-501. PMID: 9253712
- Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. | Heinrich, PC., et al. 1998. Biochem J. 334 (Pt 2): 297-314. PMID: 9716487
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-CD130/gp130 Antibody (A-12) | sc-377572 | 200 µg/ml | $322.00 | |||
p-CD130/gp130 Antibody (A-12): m-IgG2a BP-HRP Bundle | sc-545955 | 200 µg Ab; 10 µg BP | $361.00 | |||
p-CD130/gp130 Antibody (A-12) AC | sc-377572 AC | 500 µg/ml, 25% agarose | $424.00 | |||
p-CD130/gp130 Antibody (A-12) HRP | sc-377572 HRP | 200 µg/ml | $322.00 | |||
p-CD130/gp130 Antibody (A-12) FITC | sc-377572 FITC | 200 µg/ml | $336.00 | |||
p-CD130/gp130 Antibody (A-12) PE | sc-377572 PE | 200 µg/ml | $349.00 | |||
p-CD130/gp130 Antibody (A-12) Alexa Fluor® 488 | sc-377572 AF488 | 200 µg/ml | $364.00 | |||
p-CD130/gp130 Antibody (A-12) Alexa Fluor® 546 | sc-377572 AF546 | 200 µg/ml | $364.00 | |||
p-CD130/gp130 Antibody (A-12) Alexa Fluor® 594 | sc-377572 AF594 | 200 µg/ml | $364.00 | |||
p-CD130/gp130 Antibody (A-12) Alexa Fluor® 647 | sc-377572 AF647 | 200 µg/ml | $364.00 | |||
p-CD130/gp130 Antibody (A-12) Alexa Fluor® 680 | sc-377572 AF680 | 200 µg/ml | $364.00 | |||
p-CD130/gp130 Antibody (A-12) Alexa Fluor® 790 | sc-377572 AF790 | 200 µg/ml | $364.00 | |||
p-CD130/gp130 (A-12) Neutralizing Peptide | sc-377572 P | 100 µg/0.5 ml | $69.00 |