p-DAPK Antibody (DKPS308): sc-57540
- p-DAPK Antibody (DKPS308) is a mouse monoclonal IgG1 provided at 100 µl ascites
- raised against synthetic peptide corresponding to amino acids Ser 308 containing phosphorylated Ser 308 of DAPK of human origin
- recommended for detection of Ser 308 phosphorylated DAPK of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-DAPK Antibody (DKPS308). This work is in progress.
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p-DAPK Antibody (DKPS308) is a mouse monoclonal IgG1 antibody that detects Ser 308 phosphorylated DAPK in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). p-DAPK (DKPS308) antibody is available in a non-conjugated form, allowing for versatile applications in various experimental setups. Death-associated protein kinase (DAPK) plays a crucial role in regulating apoptosis, a vital process for maintaining cellular homeostasis and eliminating damaged or potentially cancerous cells. DAPK is primarily located in the cytoplasm and can translocate to the nucleus in response to apoptotic signals, highlighting DAPK′s importance in cellular decision-making processes. Phosphorylation of DAPK at Ser 308 modulates kinase activity and ability to induce apoptosis. This regulation is essential for understanding how DAPK functions in different cellular contexts, especially in cancer biology, where apoptosis evasion is a hallmark of tumor progression. DAPK interacts with various proteins involved in apoptotic signaling pathways, further underscoring DAPK′s role as a critical mediator in the balance between cell survival and death.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p-DAPK Antibody (DKPS308) References:
- A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK. | Jin, Y., et al. 2002. J Biol Chem. 277: 46980-6. PMID: 12351649
- DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury. | Schumacher, AM., et al. 2002. Biochim Biophys Acta. 1600: 128-37. PMID: 12445468
- Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome. | Narayan, G., et al. 2003. Mol Cancer. 2: 24. PMID: 12773202
- Expression of a novel type I keratin, DAPK-1 in the dorsal aorta and pronephric duct of the zebrafish embryos. | Jang, WS., et al. 2003. Gene. 312: 145-50. PMID: 12909350
- Promoter methylation and down-regulation of DAPK is associated with gastric atrophy. | Kim, WS., et al. 2003. Int J Mol Med. 12: 827-30. PMID: 14612952
- Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK. | Chen, CH., et al. 2005. EMBO J. 24: 294-304. PMID: 15616583
- Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively. | Feinstein, E., et al. 1995. Genomics. 29: 305-7. PMID: 8530096
- DAP kinase links the control of apoptosis to metastasis. | Inbal, B., et al. 1997. Nature. 390: 180-4. PMID: 9367156
- ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. | Kawai, T., et al. 1998. Mol Cell Biol. 18: 1642-51. PMID: 9488481
- Molecular cloning and developmental expression of a rat homologue of death-associated protein kinase in the nervous system. | Sakagami, H. and Kondo, H. 1997. Brain Res Mol Brain Res. 52: 249-56. PMID: 9495546
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-DAPK Antibody (DKPS308) | sc-57540 | 100 µl ascites | $316.00 |