P-cadherin Antibody (12H6): sc-53981

P-cadherin Antibody (12H6) is a mouse monoclonal IgG1 antibody that detects P-cadherin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). P-cadherin, a member of the cadherin family, plays a crucial role in cell adhesion and is essential for maintaining tissue integrity and architecture. P-cadherin is primarily located at the cell membrane, where P-cadherin forms adherens junctions that facilitate strong intercellular connections. Proper localization of P-cadherin is vital for cellular signaling and communication, influencing processes such as tissue morphogenesis and repair. Additionally, P-cadherin′s interaction with cytoplasmic proteins, including β-catenin, is significant for regulating adhesive properties and signaling pathways, which can impact cellular behavior in both normal and pathological states. Anti-P-cadherin antibody (12H6) is an invaluable tool for researchers studying the dynamics of cell adhesion and the implications of cadherin function in various diseases, including cancer, where altered expression of P-cadherin can contribute to tumor progression and metastasis.

The preferred P-cadherin antibody is P-cadherin Antibody (A-10): sc-74545.