p-Src Antibody (H-8): sc-166859

p-c-Src Antibody (H-8) is a mouse monoclonal IgG2b antibody raised against human c-Src, also known as pp60Src, Src p60, and proto-oncogene tyrosine protein kinase Src, a crucial member of the Src gene family of membrane-associated tyrosine kinases. p-c-Src mouse monoclonal antibody (H-8) recognizes an epitope within c-Src and demonstrates broad species cross-reactivity, detecting c-Src in mouse, rat, and human samples through Western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry on paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications. The Src gene family comprises nine members that maintain inactive states until specific cellular processes, such as mitosis, trigger their activation to regulate proliferation, differentiation, motility, and adhesion. c-Src′s structural organization includes an amino-terminal cell membrane anchor followed by SH3 and SH2 domains, which facilitate c-Src′s crucial role in signal transduction. c-Src shows particularly high expression in neuronal tissues and platelets, where c-Src contributes to neuronal differentiation and maintains mature neuronal cell functions. The ability of c-Src to distribute across different subcellular compartments proves essential for regulating specific cellular processes, including mitogenesis and cytoskeletal organization. Anti-p-c-Src monoclonal antibody (H-8) serves as an invaluable tool for researchers investigating these critical cellular pathways and regulatory mechanisms.

The preferred Src antibody is Src Antibody (B-12): sc-8056.