p-Bcl-2 Antibody (367.Ser 70): sc-293128

p-Bcl-2 Antibody (367.Ser 70) is a mouse monoclonal IgG1 antibody that detects Ser 70 phosphorylated Bcl-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-p-Bcl-2 antibody (367.Ser 70) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. Bcl-2 plays a crucial role in regulating apoptosis, a vital process for maintaining cellular homeostasis and development. Bcl-2 is primarily located in the outer mitochondrial membrane, where Bcl-2 exerts anti-apoptotic effects by preventing cytochrome c release, a key factor in the apoptotic cascade. Through stabilizing the mitochondrial membrane, Bcl-2 effectively inhibits downstream apoptotic pathway activation, promoting cell survival. Bcl-2′s membrane association allows direct interactions with pro-apoptotic proteins, influencing the balance between cell survival and death. Dysregulation of Bcl-2, often due to mutations or aberrant expression, can lead to various cancers by disrupting normal apoptotic processes, highlighting Bcl-2′s significance in both health and disease.

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p-Bcl-2 Antibody (367.Ser 70) References:

1. Activated Ha-ras induces apoptosis by association with phosphorylated Bcl-2 in a mitogen-activated protein kinase-independent manner.  |  Navarro, P., et al. 1999. J Biol Chem. 274: 18857-63. PMID: 10383381
2. Discovery of a small-molecule pBcl-2 inhibitor that overcomes pBcl-2-mediated resistance to apoptosis.  |  Song, T., et al. 2015. Chembiochem. 16: 757-65. PMID: 25711460
3. Cysteinyl leukotriene receptor antagonists induce apoptosis and inhibit proliferation of human glioblastoma cells by downregulating B-cell lymphoma 2 and inducing cell cycle arrest.  |  Piromkraipak, P., et al. 2018. Can J Physiol Pharmacol. 96: 798-806. PMID: 29726704
4. A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression.  |  Chong, SJF., et al. 2019. Cancer Lett. 457: 151-167. PMID: 31103719
5. JNK and phosphorylated Bcl-2 predict multiple sclerosis clinical activity and glatiramer acetate therapeutic response.  |  Anselmo, F., et al. 2020. Clin Immunol. 210: 108297. PMID: 31698073
6. Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism.  |  Chong, SJF., et al. 2020. Nucleic Acids Res. 48: 12727-12745. PMID: 33245769
7. 2B4 inhibits the apoptosis of natural killer cells through phosphorylated extracellular signal-related kinase/B-cell lymphoma 2 signal pathway.  |  Mou, J., et al. 2023. Cytotherapy. 25: 1080-1090. PMID: 37516949
8. B-cell lymphoma-2 phosphorylation at Ser70 site-related autophagy mediates puerarin-inhibited the apoptosis of MC3T3-E1 cells during osteoblastogenesis.  |  Xi, LI., et al. 2024. J Tradit Chin Med. 44: 27-34. PMID: 38213236
9. Calphostin C synergistically induces apoptosis with VP-16 in lymphoma cells which express abundant phosphorylated Bcl-2 protein.  |  Murata, M., et al. 1997. Cell Mol Life Sci. 53: 737-43. PMID: 9368670
10. Decreased levels of p26-Bcl-2, but not p30 phosphorylated Bcl-2, precede TGFbeta1-induced apoptosis in colorectal adenoma cells.  |  Hague, A., et al. 1998. Carcinogenesis. 19: 1691-5. PMID: 9771943

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Bcl-2 Antibody (367.Ser 70) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Bcl-2 Antibody (367.Ser 70) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Bcl-2 Antibody (367.Ser 70) Specifications

Alternate Product Name: Bcl-2

Product Clone Name: 367.Ser 70

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ lambda light chain

Amino Acids: Ser 70

Epitope Target: Bcl-2

Epitope Species: human

Product Reactivity/Detection: Ser 70 phosphorylated Bcl-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for p-Bcl-2 Antibody (367.Ser 70): AC: Agarose, HRP: Horseradish Peroxidase

The preferred Bcl-2 antibody is Bcl-2 Antibody (C-2): sc-7382.