OXSR1 Antibody (A-4): sc-271707

OXSR1 Antibody (A-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects OXSR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OXSR1 (A-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The oxidative stress-responsive 1 protein (OXSR1), consisting of 527 amino acids, is a member of the STE20 subfamily of serine/threonine kinases and serves a critical role in cellular responses to osmotic stress, particularly in activating downstream signaling pathways. OXSR1 is specifically activated by osmotic stresses such as sorbitol and, to a lesser extent, sodium chloride, which is vital for maintaining cellular homeostasis under stress conditions. Additionally, OXSR1 interacts with chloride channel proteins, including SLC12A1, SLC12A2, and SLC12A6 isoform 2, facilitating regulation of ion transport and cellular volume. Phosphorylation of OXSR1 by WNK1 and WNK4 protein kinases at its T-loop is essential for activation, highlighting intricate regulatory mechanisms that govern function. Widespread expression of OXSR1 in mammalian tissues underscores importance in various physiological processes, making anti-OXSR1 antibody (A-4) a valuable tool for researchers studying stress response pathways and related cellular functions.

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OXSR1 Antibody (A-4) References:

1. Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3.  |  Tamari, M., et al. 1999. J Hum Genet. 44: 116-20. PMID: 10083736
2. Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.  |  Chen, W., et al. 2004. J Biol Chem. 279: 11129-36. PMID: 14707132
3. The novel molecule porcine OSR1 up-regulated expression on porcine endothelial cell by human peripheral blood mononuclear cell activation.  |  Hu, W., et al. 2004. Transplant Proc. 36: 2475-7. PMID: 15561286
4. Hypotonic shock mediation by p38 MAPK, JNK, PKC, FAK, OSR1 and SPAK in osmosensing chloride secreting cells of killifish opercular epithelium.  |  Marshall, WS., et al. 2005. J Exp Biol. 208: 1063-77. PMID: 15767308
5. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.  |  Vitari, AC., et al. 2005. Biochem J. 391: 17-24. PMID: 16083423

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OXSR1 Antibody (A-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-OXSR1 Antibody (A-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OXSR1 Antibody (A-4) Specifications

Alternate Product Name: OXSR1

Product Clone Name: A-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 6-27

Epitope Target: OXSR1

Epitope Species: human

Product Reactivity/Detection: OXSR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for OXSR1 Antibody (A-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin