OXA1L Antibody (H-4): sc-365534
- OXA1L Antibody (H-4) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 387-413 near the C-terminus of OXA1L of mouse origin
- recommended for detection of OXA1L of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for OXA1L Antibody (H-4). This work is in progress.
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OXA1L Antibody (H-4) is a mouse monoclonal IgM antibody that detects OXA1L in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OXA1L, also known as oxidase (cytochrome c) assembly 1-like, is a crucial 435 amino acid protein located in the mitochondrial inner membrane, where OXA1L plays a vital role in the biogenesis of integral membrane proteins. OXA1L is a member of the Oxa1/Alb3/YidC family, which is essential for the proper assembly and function of key components of the oxidative phosphorylation system, including cytochrome oxidase and ATP synthase. Correct localization of OXA1L within the mitochondria is critical, as OXA1L facilitates the insertion of these integral membrane proteins, thereby ensuring efficient energy production and cellular respiration. Disruptions in OXA1L function, often due to mutations in its encoding gene, can lead to severe metabolic disorders characterized by combined enzymatic deficiencies in the oxidative phosphorylation pathway, highlighting OXA1L importance in maintaining cellular energy homeostasis. Anti-OXA1L antibody (H-4) is an invaluable tool for researchers studying mitochondrial function and related pathologies.
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OXA1L Antibody (H-4) References:
- Mutation detection in four candidate genes (OXA1L, MRS2L, YME1L and MIPEP) for combined deficiencies in the oxidative phosphorylation system. | Coenen, MJ., et al. 2005. J Inherit Metab Dis. 28: 1091-7. PMID: 16435202
- Cardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis. | Lee, RG., et al. 2020. J Cell Sci. 133: PMID: 32576663
- Elongational stalling activates mitoribosome-associated quality control. | Desai, N., et al. 2020. Science. 370: 1105-1110. PMID: 33243891
- LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding. | Shin, CS., et al. 2021. Nat Commun. 12: 265. PMID: 33431889
- Identification of Potential Therapeutic Targets and Molecular Regulatory Mechanisms for Osteoporosis by Bioinformatics Methods. | Zhang, L., et al. 2021. Biomed Res Int. 2021: 8851421. PMID: 33778083
- Translation of MT-ATP6 pathogenic variants reveals distinct regulatory consequences from the co-translational quality control of mitochondrial protein synthesis. | Ng, KY., et al. 2022. Hum Mol Genet. 31: 1230-1241. PMID: 34718584
- Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors. | Dennerlein, S., et al. 2021. Elife. 10: PMID: 34969438
- Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen. | Wotton, JM., et al. 2022. Pain. 163: 1139-1157. PMID: 35552317
- Integrative exploration of the mutual gene signatures and immune microenvironment between benign prostate hyperplasia and castration-resistant prostate cancer. | Wu, F., et al. 2023. Aging Male. 26: 2183947. PMID: 36974949
- Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria. | Poerschke, S., et al. 2024. Mol Cell. 84: 345-358.e5. PMID: 38199007
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OXA1L Antibody (H-4) | sc-365534 | 200 µg/ml | $322.00 | |||
OXA1L (H-4) Neutralizing Peptide | sc-365534 P | 100 µg/0.5 ml | $69.00 |