OXA1L Antibody (F-8): sc-365767

OXA1L Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects OXA1L in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OXA1L, also known as oxidase (cytochrome c) assembly 1-like, is a crucial 435 amino acid protein located in the mitochondrial inner membrane and is a member of the highly conserved Oxa1/Alb3/YidC protein family, which plays a vital role in the biogenesis of membrane proteins across mitochondria, chloroplasts, and bacteria. The proper localization of OXA1L within the mitochondrial inner membrane is essential for its function, as OXA1L facilitates the insertion of integral membrane proteins, thereby ensuring the correct assembly and activity of key components of the oxidative phosphorylation system, including cytochrome oxidase, F(1)F(0)-ATP synthase, and NADH:ubiquinone oxidoreductase. Disruptions in OXA1L function due to mutations in its encoding gene can lead to severe metabolic disorders characterized by combined enzymatic deficiencies in the oxidative phosphorylation pathway, highlighting the importance of OXA1L in cellular energy production and overall mitochondrial health. Anti-OXA1L antibody (F-8) is an invaluable tool for researchers studying mitochondrial function and related pathologies.

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OXA1L Antibody (F-8) References:

1. Knockdown of human Oxa1l impairs the biogenesis of F1Fo-ATP synthase and NADH:ubiquinone oxidoreductase.  |  Stiburek, L., et al. 2007. J Mol Biol. 374: 506-16. PMID: 17936786
2. Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes.  |  Haque, ME., et al. 2010. J Biol Chem. 285: 28353-62. PMID: 20601428
3. Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L.  |  Haque, ME., et al. 2010. J Biol Chem. 285: 34991-8. PMID: 20739282
4. OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect.  |  Thompson, K., et al. 2018. EMBO Mol Med. 10: PMID: 30201738
5. Mechanism of membrane-tethered mitochondrial protein synthesis.  |  Itoh, Y., et al. 2021. Science. 371: 846-849. PMID: 33602856
6. Purification of Mitochondrial Ribosomes with the Translocase Oxa1L from HEK Cells.  |  Yang, H. and Desai, N. 2021. Bio Protoc. 11: e4110. PMID: 34458404
7. Identification of miRNA-mRNA Regulatory Networks Associated with Diabetic Retinopathy using Bioinformatics Analysis.  |  Xu, W., et al. 2023. Endocr Metab Immune Disord Drug Targets. 23: 1628-1636. PMID: 37114785
8. Mitochondrial protein synthesis quality control.  |  Koludarova, L. and Battersby, BJ. 2024. Hum Mol Genet. 33: R53-R60. PMID: 38280230
9. The OXA1L gene that controls cytochrome oxidase assembly maps to the 14q11.2 region of the human genome.  |  Molina-Gomes, D., et al. 1995. Genomics. 30: 396-8. PMID: 8586451
10. Sequence and structure of the human OXA1L gene and its upstream elements.  |  Rötig, A., et al. 1997. Biochim Biophys Acta. 1361: 6-10. PMID: 9247084

The preferred OXA1L antibody is OXA1L Antibody (A-6): sc-373881.