Ox40L Antibody (G-14): sc-80269
- Ox40L Antibody (G-14) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against the extracellular domain of Ox40L of human origin
- recommended for detection of Ox40L of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ox40L Antibody (G-14). This work is in progress.
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Ox40L Antibody (G-14) is a mouse monoclonal IgG1 antibody that detects Ox40L in human samples through western blotting (WB). Ox40L, also known as gp34, is a type II membrane protein that plays a pivotal role in immune responses as a member of the tumor necrosis factor (TNF) superfamily. Anti-Ox40L antibody (G-14) is crucial for studying interactions between dendritic cells and T cells, as well as T cell homing and B cell activation. The engagement of Ox40L with its receptor, Ox40, provides a potent costimulatory signal essential for the activation and proliferation of effector T cells. Notably, Ox40L is predominantly expressed on activated B cells, while its receptor, Ox40, is found on activated T cells, highlighting the importance of this interaction in regulating immune responses. The structural characteristics of Ox40L, including its lack of a signal peptide, underscore its role as a membrane-bound protein that is integral to the immune synapse formation. Understanding the dynamics of Ox40L and its interactions is vital for developing therapeutic strategies aimed at modulating immune responses in various diseases, including cancer and autoimmune disorders. Ox40L monoclonal antibody (G-14) is an essential tool for researchers investigating the complexities of T cell activation and the broader implications of immune regulation.
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Ox40L Antibody (G-14) References:
- Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease. | Souza, HS., et al. 1999. Gut. 45: 856-63. PMID: 10562584
- Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. | Murata, K., et al. 2002. J Immunol. 169: 4628-36. PMID: 12370402
- Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. | Takeda, I., et al. 2004. J Immunol. 172: 3580-9. PMID: 15004159
- OX40 ligand shuts down IL-10-producing regulatory T cells. | Ito, T., et al. 2006. Proc Natl Acad Sci U S A. 103: 13138-43. PMID: 16924108
- Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization. | Müller, N., et al. 2008. FEBS J. 275: 2296-304. PMID: 18397322
- Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses. | Wang, YH. and Liu, YJ. 2009. Clin Exp Allergy. 39: 798-806. PMID: 19400908
- OX40-OX40 ligand interaction may activate phospholipase C signal transduction pathway in human umbilical vein endothelial cells. | Yan, J., et al. 2009. Chem Biol Interact. 180: 460-4. PMID: 19416722
- Interruption of the OX40-OX40 ligand pathway in LDL receptor-deficient mice causes regression of atherosclerosis. | Foks, AC., et al. 2013. J Immunol. 191: 4573-80. PMID: 24068673
- OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy. | Shibahara, I., et al. 2015. Mol Cancer. 14: 41. PMID: 25744203
- Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation. | Di, C., et al. 2015. J Biol Chem. 290: 12523-36. PMID: 25839234
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ox40L Antibody (G-14) | sc-80269 | 100 µg/ml | $316.00 |