Ox40L Antibody (RR19): sc-80271

Ox40L Antibody (RR19) is a mouse monoclonal IgG1 kappa light chain antibody that detects human Ox40L by immunofluorescence (IF) and flow cytometry (FCM). Anti-Ox40L antibody (RR19) is available as a non-conjugated format. Ox40L, also known as gp34, is a type II membrane protein characterized by the absence of a signal peptide, which is crucial for function as a costimulatory molecule within the tumor necrosis factor (TNF) superfamily. Ox40L plays a vital role in mediating interactions between dendritic cells and T cells, facilitating T cell homing, and promoting B cell activation. Ox40L engagement with Ox40 receptor provides a potent costimulatory signal essential for activation and proliferation of effector T cells. Ox40L is predominantly expressed on activated B cells, while Ox40 receptor is found on activated T cells, highlighting this interaction′s importance in immune response. Ox40L is integral to antigen-specific T cell responses in vivo, influencing both priming and effector phases of T cell activation when presented on antigen-presenting cells (APCs). Understanding Ox40L dynamics and interactions is crucial for developing therapeutic strategies aimed at modulating immune responses in various diseases, including cancer and autoimmune disorders.

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Ox40L Antibody (RR19) References:

1. Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions.  |  Chen, AI., et al. 1999. Immunity. 11: 689-98. PMID: 10626891
2. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand.  |  Murata, K., et al. 2000. J Exp Med. 191: 365-74. PMID: 10637280
3. Engagement of the OX-40 receptor in vivo enhances antitumor immunity.  |  Weinberg, AD., et al. 2000. J Immunol. 164: 2160-9. PMID: 10657670
4. CD134L engagement enhances human B cell Ig production: CD154/CD40, CD70/CD27, and CD134/CD134L interactions coordinately regulate T cell-dependent B cell responses.  |  Morimoto, S., et al. 2000. J Immunol. 164: 4097-104. PMID: 10754303
5. Upregulation of OX40-OX40 ligand system on T lymphocytes in patients with acute coronary syndromes.  |  Yan, J., et al. 2009. J Cardiovasc Pharmacol. 54: 451-5. PMID: 19738490
6. Blockade of OX40/OX40 ligand to decrease cytokine messenger RNA expression in acute renal allograft rejection in vitro.  |  Wang, YL., et al. 2013. Transplant Proc. 45: 2565-8. PMID: 23953582
7. Eosinophilic inflammation of chronic rhinosinusitis with nasal polyps is related to OX40 ligand expression.  |  Boita, M., et al. 2015. Innate Immun. 21: 167-74. PMID: 24583911
8. Correlation of OX40 ligand on B cells with serum total IgE and IL-4 levels by CD4+ T cells in allergic rhinitis.  |  Fouladi, S., et al. 2019. Allergol Immunopathol (Madr). 47: 234-240. PMID: 30454861
9. Extracellular vesicles produced by immunomodulatory cells harboring OX40 ligand and 4-1BB ligand enhance antitumor immunity.  |  Semionatto, IF., et al. 2020. Sci Rep. 10: 15160. PMID: 32939048
10. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.  |  Hahne, M., et al. 1998. J Exp Med. 188: 1185-90. PMID: 9743536

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ox40L Antibody (RR19) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Ox40L Antibody (RR19) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ox40L Antibody (RR19) Specifications

Alternate Product Name: Ox40L

Product Clone Name: RR19

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Ox40L

Epitope Species: human

Product Reactivity/Detection: Ox40L

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Ox40L Antibody (RR19): L: Azide-Free