Ox40L Antibody (ANC10G1): sc-65282
- Ox40L Antibody (ANC10G1) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against HUVEC and Recombinant soluble CD134L of human origin
- recommended for detection of Ox40L of human origin by FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ox40L Antibody (ANC10G1). This work is in progress.
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Ox40L Antibody (ANC10G1) is a mouse monoclonal IgG1 antibody that detects Ox40L in human samples through flow cytometry (FCM). Ox40L, also known as gp34, is a type II membrane protein that plays a pivotal role in the immune response as a member of the tumor necrosis factor (TNF) superfamily. Ox40L (ANC10G1) antibody helps study a protein crucial for facilitating interactions between dendritic cells and T cells, which are essential for effective immune responses. Specifically, Ox40L is expressed on activated B cells and interacts with its receptor, Ox40, found on activated T cells, delivering a potent costimulatory signal that enhances T cell activation and proliferation. Anti-Ox40L antibody (ANC10G1) aids in studying a protein that influences antigen-specific T cell responses, particularly during the priming and effector phases of T cell activation, when expressed on antigen-presenting cells (APCs). Understanding the dynamics of Ox40L and its interactions is vital for developing therapeutic strategies aimed at modulating immune responses in various diseases, including cancer and autoimmune disorders.
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Ox40L Antibody (ANC10G1) References:
- Expression of OX40 and OX40 ligand (gp34) in the normal and myasthenic thymus. | Onodera, J., et al. 2000. Acta Neurol Scand. 102: 236-43. PMID: 11071109
- OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity. | Soroosh, P., et al. 2006. J Immunol. 176: 5975-87. PMID: 16670306
- OX40 ligand and OX40 are increased in atopic dermatitis lesions but do not correlate with clinical severity. | Ilves, T. and Harvima, IT. 2013. J Eur Acad Dermatol Venereol. 27: e197-205. PMID: 22646697
- Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction. | Song, Y., et al. 2014. Br J Pharmacol. 171: 4955-69. PMID: 24930776
- Immunostimulation by OX40 Ligand Transgenic Ewing Sarcoma Cells. | Reuter, D., et al. 2015. Front Oncol. 5: 242. PMID: 26579494
- OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. | Hirano, T., et al. 2016. EMBO Mol Med. 8: 422-36. PMID: 26976612
- OX40 ligand is inhibitory during the effector phase of crescentic glomerulonephritis. | Odobasic, D., et al. 2019. Nephrol Dial Transplant. 34: 429-441. PMID: 29939347
- Increased Expressions of OX40 and OX40 Ligand in Patients with Primary Immune Thrombocytopenia. | Cui, D., et al. 2019. J Immunol Res. 2019: 6804806. PMID: 30944836
- High Serum OX40 and OX40 Ligand (OX40L) Levels Correlate with Reduced Survival in Patients with Advanced Lung Adenocarcinoma. | Kashima, J., et al. 2020. Oncology. 98: 303-310. PMID: 32097938
- Clinical Significance of OX40 and OX40 Ligand in the Peripheral Blood of Patients with Myasthenia Gravis. | Zhou, X., et al. 2022. J Immunol Res. 2022: 4337399. PMID: 35265719
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ox40L Antibody (ANC10G1) | sc-65282 | 100 µg/ml | $316.00 |