Ox40L Antibody (3H1846): sc-71771
- Ox40L Antibody (3H1846) is a rat monoclonal IgG1 provided at 200 µg/ml
- raised against rat and mouse CD4 and mouse CD134 ligand Chimaeric protein
- recommended for detection of Ox40L of mouse origin by FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ox40L Antibody (3H1846). This work is in progress.
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Ox40L Antibody (3H1846) is a rat monoclonal IgG1 antibody that detects Ox40L in mouse samples through flow cytometry (FCM). Ox40L, also known as gp34, is a type II membrane protein that plays a pivotal role in the immune response as a member of the tumor necrosis factor (TNF) superfamily. Ox40L is primarily expressed on activated B cells and is crucial for facilitating interactions between dendritic cells and T cells, which are essential for effective immune responses. The engagement of Ox40L with its receptor, Ox40, provides a strong costimulatory signal that enhances the activation and proliferation of effector T cells. This interaction is particularly important during the priming and effector phases of T cell activation, as Ox40L significantly influences antigen-specific T cell responses in vivo. Understanding the function of Ox40L is vital, as Ox40L not only contributes to T cell homing and B cell activation but also has implications in various immunological disorders and therapeutic strategies, making Ox40L a key target for research in immunology and cancer therapy.
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Ox40L Antibody (3H1846) References:
- Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis. | Yoshioka, T., et al. 2000. Eur J Immunol. 30: 2815-23. PMID: 11069062
- Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. | Liu, YJ. 2007. J Allergy Clin Immunol. 120: 238-44; quiz 245-6. PMID: 17666213
- OX40 ligand regulates splenic CD8⁻ dendritic cell-induced Th2 responses in vivo. | Kamachi, F., et al. 2014. Biochem Biophys Res Commun. 444: 235-40. PMID: 24462862
- Effects of OX40-OX40 ligand interaction on the levels of ROS and Cyclophilin A in C57BL/6J mice atherogenesis. | Yan, J., et al. 2014. Int J Cardiol. 176: 405-12. PMID: 25115246
- The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice. | Sitrin, J., et al. 2017. J Immunol. 199: 1238-1249. PMID: 28696253
- Characterization of a novel OX40 ligand and CD40 ligand-expressing oncolytic adenovirus used in the PeptiCRAd cancer vaccine platform. | Ylösmäki, E., et al. 2021. Mol Ther Oncolytics. 20: 459-469. PMID: 33718594
- In Situ Reprogramming of Tumors for Activating the OX40/OX40 Ligand Checkpoint Pathway and Boosting Antitumor Immunity. | Gao, Y., et al. 2022. ACS Biomater Sci Eng.. PMID: 35653749
- Amygdalin Improves Allergic Asthma via the Thymic Stromal Lymphopoietin-dendritic Cell-OX40 Ligand Axis in a Mouse Model. | Cui, W., et al. 2023. Iran J Allergy Asthma Immunol. 22: 430-439. PMID: 38085145
- Non-viral-mediated gene transfer of OX40 ligand for tumor immunotherapy. | Rakitina, OA., et al. 2024. Front Immunol. 15: 1410564. PMID: 39007148
- OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. | al-Shamkhani, A., et al. 1996. Eur J Immunol. 26: 1695-9. PMID: 8765008
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ox40L Antibody (3H1846) | sc-71771 | 200 µg/ml | $316.00 | |||
Ox40L Antibody (3H1846) FITC | sc-71771 FITC | 200 µg/ml | $330.00 | |||
Ox40L Antibody (3H1846) PE | sc-71771 PE | 200 µg/ml | $343.00 |