OX2 Antibody (OX104): sc-53098
- OX2 Antibody (OX104) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant OX2CD4d3+4CD4d3+4 of human origin
- recommended for detection of OX2 cell surface antigen of human origin by FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for OX2 Antibody (OX104). These reagents are now offered in bundles with OX2 Antibody (OX104) (see ordering information below).
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OX2 Antibody (OX104) is a mouse monoclonal IgG1 antibody that detects OX2 in human samples through flow cytometry (FCM). OX2, also known as CD200, is a critical member of the immunoglobulin superfamily (IgSF) and functions as a cell surface glycoprotein composed of 248 amino acids. OX2 plays a vital role in modulating immune responses by interacting with OX2R, which is predominantly expressed in lymphoid and neuronal tissues. The interaction between OX2 and OX2R helps regulate inflammatory responses, particularly by suppressing macrophage activation, thereby preventing excessive tissue damage during immune reactions. OX2R is characterized by a high degree of N-linked glycosylation, accounting for up to 70% of molecular weight, which is essential for stability and function. The cytoplasmic domain of OX2R contains NPXY motifs that facilitate interactions with specific binding domains, further underscoring OX2′s importance in maintaining immune homeostasis. With unique properties and a critical role in immune regulation, anti-OX2 antibody (OX104) serves as an invaluable tool for researchers studying immune responses and related pathways in human tissues.
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OX2 Antibody (OX104) References:
- Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. | Wright, GJ., et al. 2000. Immunity. 13: 233-42. PMID: 10981966
- Distribution of OX2 antigen and OX2 receptor within retina. | Dick, AD., et al. 2001. Invest Ophthalmol Vis Sci. 42: 170-6. PMID: 11133863
- The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. | Wright, GJ., et al. 2001. Immunology. 102: 173-9. PMID: 11260322
- Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth. | Gorczynski, RM. 2001. Arch Immunol Ther Exp (Warsz). 49: 303-9. PMID: 11726033
- OX1 and OX2 orexin/hypocretin receptor pharmacogenetics. | Thompson, MD., et al. 2014. Front Neurosci. 8: 57. PMID: 24834023
- Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors. | Yin, J., et al. 2016. Nat Struct Mol Biol. 23: 293-9. PMID: 26950369
- Pharmacophore Model To Discover OX1 and OX2 Orexin Receptor Ligands. | Turku, A., et al. 2016. J Med Chem. 59: 8263-75. PMID: 27546834
- Effects of concurrent blockade of OX2 and CB1 receptors in the ventral tegmental area on nicotine-induced place preference in rats. | Azizi, F., et al. 2018. Neurosci Lett. 684: 121-126. PMID: 30017709
- Functional crosstalk of nucleus accumbens CB1 and OX2 receptors in response to nicotine-induced place preference. | Fartootzadeh, R., et al. 2019. Neurosci Lett. 698: 160-164. PMID: 30659912
- The leukocyte/neuron cell surface antigen OX2 binds to a ligand on macrophages. | Preston, S., et al. 1997. Eur J Immunol. 27: 1911-8. PMID: 9295026
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OX2 Antibody (OX104) | sc-53098 | 200 µg/ml | $322.00 | |||
OX2 Antibody (OX104): m-IgGκ BP-HRP Bundle | sc-534060 | 200 µg Ab; 40 µg BP | $361.00 | |||
OX2 Antibody (OX104): m-IgG1 BP-HRP Bundle | sc-538856 | 200 µg Ab; 20 µg BP | $361.00 | |||
OX2 Antibody (OX104) FITC | sc-53098 FITC | 200 µg/ml | $336.00 | |||
OX2 Antibody (OX104) PE | sc-53098 PE | 200 µg/ml | $349.00 |