OX2 Antibody (3H1979): sc-71760
- OX2 Antibody (3H1979) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant OX2CD4d3+4CD4d3+4 of human origin
- recommended for detection of OX2 cell surface antigen of human origin by FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for OX2 Antibody (3H1979). These reagents are now offered in bundles with OX2 Antibody (3H1979) (see ordering information below).
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OX2 Antibody (3H1979) is a mouse monoclonal IgG1 antibody that detects OX2 in human samples through flow cytometry (FCM). OX2, also known as CD200, is a critical member of the immunoglobulin superfamily (IgSF) and functions as a cell surface glycoprotein composed of 248 amino acids. CD200 plays a vital role in modulating immune responses by interacting with OX2R, which is predominantly expressed in lymphoid and neuronal tissues. The interaction between CD200 and OX2R helps regulate inflammatory responses, particularly by suppressing macrophage activation, thereby preventing excessive tissue damage during immune reactions. OX2R is characterized by a high degree of N-linked glycosylation, accounting for up to 70% of its molecular weight, which is essential for stability and function. The cytoplasmic domain of OX2R contains NPXY motifs that facilitate interactions with specific binding domains, further underscoring CD200′s importance in maintaining immune homeostasis. Anti-OX2 antibody (3H1979) serves as an invaluable tool for researchers studying immune regulation and related pathways in human tissues.
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OX2 Antibody (3H1979) References:
- CD157 and CD200 at the crossroads of endothelial remodeling and immune regulation. | Katoh, M. and Katoh, M. 2019. Stem Cell Investig. 6: 10. PMID: 31119148
- CD200 promotes immunosuppression in the pancreatic tumor microenvironment. | Choueiry, F., et al. 2020. J Immunother Cancer. 8: PMID: 32581043
- CD200+ cytotoxic T lymphocytes in the tumor microenvironment are crucial for efficacious anti-PD-1/PD-L1 therapy. | Wang, X., et al. 2023. Sci Transl Med. 15: eabn5029. PMID: 36652534
- CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation. | Chen, X., et al. 2023. J Neuroinflammation. 20: 157. PMID: 37391731
- Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy. | Tang, Y., et al. 2024. Blood. 143: 139-151. PMID: 37616575
- Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy. | Pfeifer, CW., et al. 2023. Proc Natl Acad Sci U S A. 120: e2308214120. PMID: 37903272
- CD200/CD200R: Bidirectional Role in Cancer Progression and Immunotherapy. | Nip, C., et al. 2023. Biomedicines. 11: PMID: 38137547
- CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis. | Rauber, S., et al. 2024. Nat Immunol. 25: 682-692. PMID: 38396288
- Single-Cell Multimodal Profiling of Atherosclerosis Identifies CD200 as a Cell Surface Lineage Marker of Vascular Smooth Muscle Cells and Their Derived Cells. | Bashore, AC., et al. 2024. Circulation. 149: 1231-1233. PMID: 38588334
- CD200 is overexpressed in the pancreatic tumor microenvironment and predictive of overall survival. | Wedig, J., et al. 2024. Cancer Immunol Immunother. 73: 96. PMID: 38619621
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OX2 Antibody (3H1979) | sc-71760 | 200 µg/ml | $322.00 | |||
OX2 Antibody (3H1979): m-IgG Fc BP-HRP Bundle | sc-539401 | 200 µg Ab; 10 µg BP | $361.00 | |||
OX2 Antibody (3H1979): m-IgG1 BP-HRP Bundle | sc-541467 | 200 µg Ab; 20 µg BP | $361.00 | |||
OX2 Antibody (3H1979) FITC | sc-71760 FITC | 200 µg/ml | $336.00 | |||
OX2 Antibody (3H1979) PE | sc-71760 PE | 200 µg/ml | $349.00 |