Ox-LDL R-1 Antibody (X-4): sc-80268

Ox-LDL R-1 Antibody (X-4) is a rat monoclonal IgG2a antibody that detects Ox-LDL R-1 of mouse origin by western blotting (WB), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-Ox-LDL R-1 antibody (X-4) is available in a non-conjugated form, specifically designed for researchers studying oxidized low-density lipoprotein (lectin-like) receptor-1, a type II membrane protein belonging to the C-type lectin family. This receptor plays a crucial role in atherosclerosis pathophysiology by mediating oxidized low-density lipoprotein (Ox-LDL) uptake, which drives monocyte-derived macrophages′ transformation into foam cells within atherosclerotic lesions. Ox-LDL and Ox-LDL R-1 interaction facilitates lipid accumulation and activates NFkB signaling pathway, leading to inflammatory responses that worsen cardiovascular diseases. Ox-LDL R-1, also known as scavenger receptor class E, member 1 (SCARE1), lectin-type oxidized LDL receptor 1 (LOX-1), and CLEC8A, is mainly expressed in vascular endothelial cells, smooth muscle cells, and macrophages. Ox-LDL R-1 exists in two forms: an endogenous precursor with N-linked high mannose carbohydrate chains and a mature form resulting from further glycosylation. N-linked glycosylation of Ox-LDL R-1 ensures proper cell surface localization and optimal ligand binding, highlighting its importance in cellular interactions and signaling pathways related to lipid metabolism and inflammation.

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Ox-LDL R-1 Antibody (X-4) References:

1. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) activity decreases estrogenesis in ovarian granulosa cells.  |  Löhrke, B., et al. 2011. Cytometry A. 79: 669-71. PMID: 21595015
2. The lectin-like oxidized low-density lipoprotein receptor-1 as therapeutic target for atherosclerosis, inflammatory conditions and longevity.  |  Ulrich-Merzenich, G. and Zeitler, H. 2013. Expert Opin Ther Targets. 17: 905-19. PMID: 23738516
3. Soluble lectin-like oxidized low density lipoprotein receptor-1 as a biochemical marker for atherosclerosis-related diseases.  |  Pirillo, A. and Catapano, AL. 2013. Dis Markers. 35: 413-8. PMID: 24198442
4. Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy.  |  Chen, M., et al. 2016. Blood Cells Mol Dis. 60: 44-8. PMID: 27519944
5. Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels as a Biomarker of Acute Intracerebral Hemorrhage.  |  Inoue, T., et al. 2019. J Stroke Cerebrovasc Dis. 28: 490-494. PMID: 30442557
6. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease.  |  Akhmedov, A., et al. 2021. Eur Heart J. 42: 1797-1807. PMID: 33159784
7. Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Inhibition in Type 2 Diabetes: Phase 1 Results.  |  Vavere, AL., et al. 2023. J Am Heart Assoc. 12: e027540. PMID: 36688371
8. Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions.  |  Truthe, S., et al. 2024. J Innate Immun. 16: 105-132. PMID: 38232720
9. Targeting Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) for Oral Squamous Cell Carcinoma management.  |  Renu, K., et al. 2024. J Stomatol Oral Maxillofac Surg. 125: 101930. PMID: 38815726
10. Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1): A Potential Therapeutic Target in Ischemic Stroke.  |  Hu, Y., et al. 2024. Transl Stroke Res.. PMID: 39576412

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ox-LDL R-1 Antibody (X-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Ox-LDL R-1 Antibody (X-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ox-LDL R-1 Antibody (X-4) Specifications

Alternate Product Name: Ox-LDL R-1

Product Clone Name: X-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: Ox-LDL R-1

Epitope Species: mouse

Product Reactivity/Detection: Ox-LDL R-1

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Ox-LDL R-1 Antibody (X-4): N/A

The preferred Ox-LDL R-1 antibody is Ox-LDL R-1 Antibody (LOX19-22): sc-66155.