OTX1 Antibody (3A5): sc-517000

OTX1 Antibody (3A5) is a mouse monoclonal IgG2a kappa light chain antibody that detects OTX1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-OTX1 antibody (3A5) is available as the non-conjugated format. OTX1 plays a crucial role in brain development, particularly in corticogenesis, sensory organ development, and pituitary functions. OTX1 is essential for the induction, specification, and regionalization of the brain, working alongside OTX2 to ensure proper brain patterning through a dosage-dependent mechanism. Precise regulation of OTX1 levels influences the positioning of the isthmic region and anterior brain patterning, which are critical for the formation of functional neural structures. OTX1 and OTX2 are necessary for the correct specification of the neuroectoderm, which ultimately gives rise to the fore-midbrain. OTX1 and OTX2 genes are located on human chromosomes 2p13 and 14q21-q22, respectively, highlighting their evolutionary conservation and importance in vertebrate development.

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OTX1 Antibody (3A5) References:

1. Otx genes and the genetic control of brain morphogenesis.  |  Acampora, D., et al. 1999. Mol Cell Neurosci. 13: 1-8. PMID: 10049527
2. Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes.  |  Acampora, D., et al. 1999. Development. 126: 1417-26. PMID: 10068635
3. The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis.  |  Acampora, D. and Simeone, A. 1999. Trends Neurosci. 22: 116-22. PMID: 10199636
4. Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.  |  Morsli, H., et al. 1999. Development. 126: 2335-43. PMID: 10225993
5. Otx genes in corticogenesis and brain development.  |  Acampora, D., et al. 1999. Cereb Cortex. 9: 533-42. PMID: 10498271
6. Genetic and molecular roles of Otx homeodomain proteins in head development.  |  Acampora, D., et al. 2000. Gene. 246: 23-35. PMID: 10767524
7. Chromosome locations of human EMX and OTX genes.  |  Kastury, K., et al. 1994. Genomics. 22: 41-5. PMID: 7959790
8. Functional equivalency between Otx2 and Otx1 in development of the rostral head.  |  Suda, Y., et al. 1999. Development. 126: 743-57. PMID: 9895322

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OTX1 Antibody (3A5) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-OTX1 Antibody (3A5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OTX1 Antibody (3A5) Specifications

Alternate Product Name: OTX1

Product Clone Name: 3A5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 10-116

Epitope Target: OTX1

Epitope Species: human

Product Reactivity/Detection: OTX1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for OTX1 Antibody (3A5): N/A