OSTF1 Antibody (AT9G4): sc-517418

OSTF1 Antibody (AT9G4) is a mouse monoclonal IgG2a kappa light chain antibody that detects OSTF1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-OSTF1 antibody (AT9G4) is available as a non-conjugated format. OSTF1, also known as osteoclast-stimulating factor 1, is a 214 amino acid cytoplasmic protein characterized by three ankyrin repeats and one SH3 domain, which plays a crucial role in mediating protein-protein interactions. The presence of the SH3 domain facilitates OSTF1 interaction with survival motor neuron (SMN) protein, which is essential for spliceosomal small nuclear ribonucleoproteins assembly. OSTF1 also interacts with Src and FAS-L, contributing to function in osteoclasts, where OSTF1 induces bone resorption through a signaling cascade that enhances osteoclast formation and activity. The gene encoding OSTF1 spans nearly 59,000 bases on human chromosome 9q21, a region housing over 900 genes associated with various genetic disorders, including hereditary hemorrhagic telangiectasia and familial dysautonomia. Chromosome 9 contains the largest cluster of interferon family genes, highlighting significance in immune response regulation.

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OSTF1 Antibody (AT9G4) References:

1. Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption.  |  Reddy, S., et al. 1998. J Cell Physiol. 177: 636-45. PMID: 10092216
2. Assignment of OSTF1 to human chromosome bands 12q24.1-->q24.2 by in situ hybridization.  |  Schaub, R., et al. 2000. Cytogenet Cell Genet. 88: 87-8. PMID: 10773673
3. Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation.  |  Kurihara, N., et al. 2001. J Biol Chem. 276: 41035-9. PMID: 11551898
4. Crystallization and preliminary X-ray crystallographic analysis of osteoclast-stimulating factor.  |  Li, M., et al. 2005. Acta Crystallogr Sect F Struct Biol Cryst Commun. 61: 128-30. PMID: 16508112
5. Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution.  |  Chen, L., et al. 2006. Acta Crystallogr Sect F Struct Biol Cryst Commun. 62: 844-8. PMID: 16946461
6. Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease).  |  Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
7. Crystal structure of human osteoclast stimulating factor.  |  Tong, S., et al. 2009. Proteins. 75: 245-51. PMID: 19137598
8. Neuroimaging supports central pathology in familial dysautonomia.  |  Axelrod, FB., et al. 2010. J Neurol. 257: 198-206. PMID: 19705052
9. Osteoclast stimulation factor 1 (Ostf1) KNOCKOUT increases trabecular bone mass in mice.  |  Vermeren, M., et al. 2017. Mamm Genome. 28: 498-514. PMID: 28936620
10. Characterization of a novel RP2-OSTF1 interaction and its implication for actin remodelling.  |  Lyraki, R., et al. 2018. J Cell Sci. 131: PMID: 29361551
11. Prognosis and therapy in thyroid cancer by gene signatures related to natural killer cells.  |  Jin, Z., et al. 2024. J Gene Med. 26: e3657. PMID: 38282150
12. OSTF1 knockdown mitigates IL-1β-induced chondrocyte injury via inhibiting the NF-κB signaling pathway.  |  Hu, B. and Du, G. 2024. Heliyon. 10: e30110. PMID: 38699012

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OSTF1 Antibody (AT9G4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-OSTF1 Antibody (AT9G4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OSTF1 Antibody (AT9G4) Specifications

Alternate Product Name: OSTF1

Product Clone Name: AT9G4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: OSTF1

Epitope Species: human

Product Reactivity/Detection: OSTF1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for OSTF1 Antibody (AT9G4): N/A